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Rabbit Anti-MPHOSPH8 Polyclonal Antibody#abs139157

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Description

Catalog-specification	Delivery time	USD price
abs139157-100ug	1-2 Weeks	301.0
abs139157-50ug	1-2 Weeks	201.0

Overview
catalog	abs139157
Other names	M-phase phosphoprotein 8, also known as HSMPP8 or MPP8, is a protein involved in the regulation of cell division. It is also referred to as MPHOSPH8 or RP11-523H24.1. MPP8 interacts with the protein RanBPM, and together they form a complex called Two hybrid-associated protein 3 or Twa3. This protein complex plays a role in various cellular processes, including cell cycle progression.
Source	Rabbit
Specificity	The total level of endogenous MPHOSPH8 can be detected using the MPHOSPH8 Antibody. To create a similar content, the text can be rearranged to state that the antibody can recognize the overall expression of MPHOSPH8 protein in the sample being analyzed.
Species Reactivity	Human;Mouse;Rat
Antigen	MPHOSPH8
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MPHOSPH8.
MW	97 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the sample, it is recommended to store it at a temperature of -20°C for a duration of one year. It is crucial to prevent the sample from undergoing repeated freeze/thaw cycles, as this can lead to unwanted changes in its composition.
Storage buffer	This product is Rabbit IgG dissolved in phosphate buffered saline at pH 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Please store it at -20 °C for optimal preservation. It remains stable for a period of 12 months from the date of receipt.
Target
Background	Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Posttranslational modification	Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q99549