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Rabbit Anti-CACNA1C Polyclonal Antibody#abs132667

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Description

Catalog-specification	Delivery time	USD price
abs132667-100ug	1-2 Weeks	301.0
abs132667-50ug	1-2 Weeks	201.0

Overview
catalog	abs132667
Description	Voltage-sensitive calcium channels (VSCC) are crucial for the entry of calcium ions into excitable cells, and are involved in a myriad of calcium-dependent processes. These processes include muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The alpha-1C isoform is responsible for the production of L-type calcium currents, which are a type of high-voltage activated (HVA) channel. These channels can be blocked by various substances, such as dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and omega-agatoxin-IIIA (omega-Aga-IIIA). However, they are insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Alpha-1C-containing calcium channels play a significant role in excitation-contraction coupling in hearts. The isoforms display differing sensitivity to DHP compounds, and binding of calmodulin or CABP1 has opposing effects on channel function.
Other names	The alpha-1 polypeptide is a crucial component of the calcium channel, specifically the L type, found in cardiac muscle. This isoform 1 is also known as CAC1C_HUMAN, CACH 2, CACH2, CACN 2, CACN2, CACNA1C, CACNL1A1, and CaV1.2. It is responsible for the dihydropyridine sensitivity of the channel, making it a target for various drugs used in the treatment of cardiovascular diseases. The voltage-dependent L type calcium channel subunit alpha-1C also goes by the names DHPR alpha 1, DHPR alpha 1 subunit, LQT8, and TS. The splice variant 10 of this channel subunit is known as voltage-gated L type calcium channel Cav1.2 alpha 1 subunit. All of these names describe the same critical protein that plays a vital role in maintaining proper cardiac function and regulation.
Source	Rabbit
Specificity	The detection of total CACNA1C is possible using the CACNA1C antibody, as it can effectively detect the endogenous levels of this protein. To generate similar content based on the given text, we can rearrange the information as follows: The endogenous levels of total CACNA1C can be accurately identified using the CACNA1C antibody. This antibody is designed to specifically detect the presence of CACNA1C and enable the measurement of its total levels in biological samples. By utilizing this antibody, researchers can explore the expression and localization of CACNA1C, thereby gaining valuable insights into its functional roles and potential implications in various physiological and pathological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	CACNA1C
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	249 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
Tissue specificity	Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.
Posttranslational modification	Phosphorylation by PKA activates the channel.
Celluar localization	Plasma Membrane;
UniPort	Q13936