Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CACNG8 Polyclonal Antibody#abs132666

Please note that the given price is for your reference only and for detailed pricing, kindly get in touch with our sales representative, Vecent. It's important to clarify that a different approach will be taken in generating the content, ensuring that the text is entirely different from the one...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs132666-100ug	1-2 Weeks	301.0
abs132666-50ug	1-2 Weeks	201.0

Overview
catalog	abs132666
Other names	CACNG; CACNG6; Cacng8; Calcium channel voltage dependent gamma subunit 8; CCG8_HUMAN; Neuronal voltage-gated calcium channel gamma-8 subunit; TARP gamma-8; Transmembrane AMPAR regulatory protein gamma-8; Voltage dependent calcium channel gamma 8 subunit; Voltage-dependent calcium channel gamma-8 subunit. The CACNG gene family, which includes CACNG, CACNG6, and Cacng8, encodes voltage-dependent calcium channel gamma subunits that play a crucial role in neuronal activity. Among these subunits, CACNG8 is specifically involved in regulating voltage-gated calcium channels in neurons. Also known as CCG8_HUMAN, the CACNG8 protein acts as a transmembrane AMPAR regulatory protein gamma-8, contributing to the modulation of AMPA receptors. These receptors are crucial for synaptic transmission and plasticity in the central nervous system. The neuronal voltage-gated calcium channel gamma-8 subunit, or TARP gamma-8, is a key component in forming functional calcium channels. It modulates the gating properties and subcellular targeting of these channels, thereby influencing synaptic transmission and neuronal excitability. Understanding the role of the voltage-dependent calcium channel gamma-8 subunit is essential for unraveling the intricacies of calcium signaling in neurons. By modulating the influx of calcium ions, this subunit contributes to various neuronal processes, such as neurotransmitter release, synaptic plasticity, and neuronal development. In summary, the CACNG, CACNG6, and Cacng8 genes encode critical subunits involved in voltage-dependent calcium channels. CACNG8, in particular, acts as a transmembrane AMPAR regulatory protein gamma-8, influencing AMPA receptors' function. Moreover, the neuronal voltage-gated calcium channel gamma-8 subunit plays a vital role in calcium channel modulation and synaptic transmission. Understanding these subunits' functions sheds light on the mechanisms underlying neuronal activity and communication in the brain.
Source	Rabbit
Specificity	The CACNG8 antibody is able to identify the full range of natural levels of CACNG8 present within an organism. This detection is achieved by targeting the entirety of CACNG8 to yield accurate results.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Dog
Antigen	CACNG8
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	43 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, keep the item stored at -20 °C for a year without subjecting it to repeated freeze/thaw cycles.
Storage buffer	In phosphate buffered saline with a pH of 7.4, there is Rabbit IgG, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. All of these components create a highly effective solution for whatever application it is being used for. It is important to note that careful consideration should be taken when handling this solution due to the presence of sodium azide. However, when used appropriately, the Rabbit IgG solution can provide great results.
Target
Background	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Celluar localization	Plasma Membrane;
UniPort	Q8WXS5