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Rabbit Anti-CACNG5 Polyclonal Antibody#abs132665

Description

Catalog-specification	Delivery time	USD price
abs132665-100ug	1-2 Weeks	301.0
abs132665-50ug	1-2 Weeks	201.0

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Overview
catalog	abs132665
Description	One suggestion for preventing the calcium channel from opening is to maintain it in its inactivated (closed) state. This can be achieved by stabilizing the channel in a closed configuration.
Other names	Cacng5, also known as calcium channel voltage-dependent gamma subunit 5, is a protein encoded by the CACNG5 gene in humans. It is also referred to as CCG5_HUMAN, MGC126656, MGC126682, neuronal voltage-gated calcium channel gamma-5 subunit, or voltage-dependent calcium channel gamma 5 subunit. This protein plays a crucial role in the function of voltage-gated calcium channels in neuronal cells. It acts as a modulator, influencing the channel's properties and activity. This modulation allows for precise control of calcium ion influx, which is essential for various cellular processes. Studies have shown that mutations in the CACNG5 gene can lead to altered calcium channel function and contribute to the development of neurological disorders. Additionally, dysregulation of calcium channels has been linked to conditions like epilepsy, ataxia, and migraine. Understanding the role of Cacng5 and its interactions with calcium channels may provide valuable insights into the pathogenesis of these disorders. Further research is necessary to uncover the precise mechanisms and potential therapeutic targets associated with this protein. In conclusion, Cacng5 is a critical component of voltage-gated calcium channels, influencing their function and playing a role in neurological processes. Investigating its role may lead to a better understanding and potential treatment options for certain neurological disorders.
Source	Rabbit
Specificity	The CACNG5 antibody is capable of detecting the overall expression of CACNG5 at its natural levels.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Pig;Dog
Antigen	CACNG5
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	31 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly similar content could be generated by rephrasing the information to read: Peptide affinity chromatography was utilized in order to purify the antiserum, which was accomplished through the use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the material at a temperature of -20 °C for a duration of one year. To preserve the quality of the substance, it is advisable to avoid repeated freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Celluar localization	Plasma Membrane;
UniPort	Q9UF02