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Rabbit Anti-PDP1 Polyclonal Antibody#abs139314

Please note that the price mentioned is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis PDP1 using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs139314-100ug	1-2 Weeks	301.0
abs139314-50ug	1-2 Weeks	201.0

Please note that the price mentioned is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs139314
Other names	Mitochondrial pyruvate dehydrogenase [acetyl-transferring] phosphatase 1, also known as PDP1 or protein phosphatase 2C, is an enzyme responsible for the dephosphorylation of pyruvate dehydrogenase (PDH) in the mitochondria. It plays a crucial role in regulating the activity of PDH, which is involved in the conversion of pyruvate to acetyl-CoA. PDP1 is encoded by the gene FLJ32517, also known as Gm1024 or MGC119646. PDP1 belongs to the phosphatase 2C family and is characterized by its magnesium-dependent catalytic activity. It acts as a key regulatory enzyme in the pyruvate dehydrogenase complex, ensuring the proper functioning of cellular energy metabolism. Dysfunction of PDP1 can lead to metabolic disorders and impairments in energy production. The protein encoded by PDP1_HUMAN, also known as RP23 203A12.1, is the catalytic subunit of pyruvate dehydrogenase phosphatase. It interacts with other subunits to form a holoenzyme complex responsible for the dephosphorylation of PDH. This enzymatic activity is essential for maintaining the balance between glycolysis and oxidative phosphorylation in mitochondria. Overall, PDP1 is an important enzyme involved in the regulation of energy metabolism, specifically in the control of pyruvate dehydrogenase activity. Its role in maintaining cellular energy homeostasis highlights its significance in various physiological processes.
Source	Rabbit
Specificity	The total PDP1 levels present in the body can be recognized with the use of PDP1 Antibody, which is capable of detecting endogenous levels of the protein. If you need to create content that is similar to this information, you could try rearranging the words and phrases used in the original text to create a fresh and unique description of the same concept.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Pig;Dog;Bovine;Sheep;
Antigen	PDP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PDP1.
MW	61 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography and purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this may cause a detrimental effect on its quality. Taking these precautions can help to maintain the efficacy and shelf life of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Celluar localization	Mitochondrion;
UniPort	Q9P0J1