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Rabbit Anti-Cacna2d1 Polyclonal Antibody#abs138030

Please be informed that the provided price is for your reference only. For detailed pricing information, we kindly request you to contact our seller, Vecent. Western blot analysis Cacna2d1 using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs138030-100ug	1-2 Weeks	301.0
abs138030-50ug	1-2 Weeks	201.0

Please be informed that the provided price is for your reference only. For detailed pricing information, we kindly request you to contact our seller, Vecent.

Overview
catalog	abs138030
Other names	CACN A2D1_HUMAN is a protein that is encoded by the CACNA2D1 gene. It is also known as CACNL2A, Calcium channel L type alpha 2 polypeptide, Calcium channel voltage dependent alpha 2/delta subunit 1, CCHL2A, Dihydropyridine receptor alpha 2 subunit, and more. This protein is a subunit of the dihydropyridine-sensitive L-type calcium channel. It plays a crucial role in regulating calcium influx into cells. The CACN A2D1_HUMAN is involved in various physiological processes, including muscle contraction, neurotransmitter release, and neuronal development. Mutations in the CACNA2D1 gene have been associated with certain types of muscular disorders, such as malignant hyperthermia susceptibility type 3 (MHS3). This protein is an essential component of voltage-gated calcium channels and helps in the modulation of channel activity. Overall, understanding the function and regulation of CACN A2D1_HUMAN is important for uncovering the mechanisms underlying calcium signaling in various cellular processes.
Source	Rabbit
Specificity	Total Cacna2d1 levels are detected by the Cacna2d1 Antibody, which specifically targets endogenous levels of the protein. Let's generate highly similar content by rearranging the above information: The Cacna2d1 Antibody is capable of detecting endogenous levels of total Cacna2d1 protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;
Antigen	Cacna2d1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Cacna2d1.
MW	123 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly refined form was produced as a result of this process.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Tissue specificity	Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
Posttranslational modification	Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	P54289