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Rabbit Anti-Brm Polyclonal Antibody#abs138029

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our sales representative Vecent. Western blot analysis Brm using HuvEc whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs138029-100ug	1-2 Weeks	301.0
abs138029-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our sales representative Vecent.

Overview
catalog	abs138029
Other names	SMARCA2, also known as ATP-dependent helicase SMARCA2, BAF190, BAF190B, or SNF2-like protein 2, is a protein involved in the regulation of gene expression through chromatin remodeling. It is a member of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A and is highly similar to the protein brahma homolog. As an ATP-dependent helicase, SMARCA2 is involved in DNA unwinding and remodeling, which allows for the access of transcription factors and other regulatory proteins to the DNA sequence. It plays a crucial role in the maintenance of chromatin structure, and its dysfunction has been implicated in several diseases, including cancer. SMARCA2 has also been identified as a possible global transcription activator, and it is thought to play a role in the regulation of growth and development. It is expressed in a wide range of tissues and is highly conserved throughout evolution. Overall, SMARCA2 is a vital component in the regulation of gene expression and the maintenance of chromatin structure. Its function is essential for normal growth and development, and its dysregulation can lead to a variety of developmental and disease-related disorders.
Source	Rabbit
Specificity	The endogenous levels of total Brm can be detected using the Brm Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	Brm
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Brm.
MW	181 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Celluar localization	Cytoskeleton;Nucleus;
UniPort	P51531