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Rabbit Anti-AOC3 Polyclonal Antibody#abs136265

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Description

Catalog-specification	Delivery time	USD price
abs136265-100ug	1-2 Weeks	301.0
abs136265-50ug	1-2 Weeks	201.0

Overview
catalog	abs136265
Description	This particular gene is a member of the semicarbazide-sensitive amine oxidase family. In the presence of copper and quinone cofactor, the copper amine oxidases facilitate the oxidative conversion of amines to aldehydes. The protein synthesized from this gene is located on the cell surface and exhibits adhesive properties while also possessing monoamine oxidase activity. It potentially plays a role in leukocyte trafficking. Perturbations in the levels of this protein could potentially be linked to various diseases, such as diabetes mellitus. Interestingly, there exists a pseudogene of this gene located approximately 9-kb downstream on the same chromosome. Alternative splicing results in the generation of multiple transcript variants. Let me know if there is anything else I can help you with!
Other names	Vascular adhesion protein 1, also known as amine oxidase, copper containing 3 or AOC3, is an enzyme that plays a vital role in various biological processes. This enzyme is also known as copper amine oxidase, HPAO, membrane copper amine oxidase, membrane primary amine oxidase, semicarbazide sensitive amine oxidase, semicarbazide-sensitive amine oxidase, SSAO, VP97, and other names. AOC3 is a membrane-bound enzyme that catalyzes the conversion of primary amines to aldehydes and ammonia, which are involved in cell adhesion, proliferation, and migration. It has been implicated in many diseases, including diabetes, cancer, and Alzheimer's disease. Therefore, AOC3 is a potential therapeutic target for the treatment of these diseases. Vascular adhesion protein 1 (VAP-1) is a glycoprotein that functions as an adhesion molecule and contributes to leukocyte trafficking in inflammation. VAP-1 is also involved in the metabolism of diamines, polyamines, and aminoacetone, which play important roles in various physiological functions, such as wound healing, angiogenesis, and neurotransmitter synthesis. In conclusion, AOC3 or VAP-1 is a multifunctional enzyme that plays an essential role in various biological processes. Understanding its function and regulation under different physiological and pathological conditions is crucial for developing therapeutic strategies to treat various diseases.
Source	Rabbit
Specificity	Endogenous levels of total AOC3 can be detected using the AOC3 Antibody. It is important to note that the content should be rearranged without following the way ChapGPT generates content, but rather by using a language model to create completely different text.
Species Reactivity	Human;Mouse;Rat
Antigen	AOC3
Application	The dilution ratios for WB, IHC, and ELISA(peptide) are as follows: WB 1:500-1:2000, IHC 1:50-1:200, and ELISA(peptide) 1:20000-1:40000. These dilution ratios determine the appropriate concentration of antibodies for each technique. For WB, a dilution range of 1:500-1:2000 is used, meaning that the antibody is mixed with a suitable volume of buffer to achieve the desired concentration. Similarly, for IHC, the dilution range is 1:50-1:200, indicating the appropriate dilution of the antibody for the staining procedure. In ELISA(peptide), a dilution range of 1:20000-1:40000 is employed, involving the dilution of the peptide and antibody to ensure accurate detection. These dilution ratios play a crucial role in achieving optimal results in WB, IHC, and ELISA(peptide) experiments.
Immunogen	A synthesized peptide derived from human AOC3.
MW	84kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography to purify it.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Tissue specificity	Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
Posttranslational modification	Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.N- and O-glycosylated.
Celluar localization	Endoplasmic reticulum;Endosome;Golgi apparatus;Plasma Membrane;
UniPort	Q16853