Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PAX8 Polyclonal Antibody#abs132985

Please note that the price mentioned is only for your reference. For detailed pricing, please contact our seller Vecent. It's important to reach out to Vecent to get the exact pricing details as the mentioned amount is just an estimate. So, connect with our seller today and get all the...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs132985-100ug	1-2 Weeks	301.0
abs132985-50ug	1-2 Weeks	201.0

Overview
catalog	abs132985
Description	To maintain the functional differentiation of thyroid cells and ensure the exclusive expression of genes specific to this cell type, a transcription factor is necessary. This factor plays a crucial role in regulating the expression of genes exclusively expressed in thyroid cells, thus preserving the unique identity of these cells. Without this factor, thyroid cells would lose their functional differentiation and fail to carry out their essential role in the body. Therefore, the transcription factor for thyroid-specific gene expression is vital for the proper functioning of the thyroid gland and overall health.
Other names	PAX8 is a crucial gene that is responsible for encoding a specific type of protein, known as the paired box protein Pax-8. This protein belongs to the paired box family of transcription factors and plays a vital role in the regulation of critical developmental processes. The PAX8 gene is also referred to as the paired box homeotic gene 8 or the paired domain gene 8. In humans, this gene is primarily expressed in the thyroid gland, where it plays a crucial role in regulating the growth and differentiation of thyroid cells. Moreover, studies have shown that mutations in the PAX8 gene can lead to a wide range of disorders, including congenital hypothyroidism, renal anomalies, and even cancer. Therefore, understanding the functions and mechanisms of this gene is essential for developing improved treatments and therapies for these conditions. In summary, PAX8 is a vital gene that encodes a vital protein involved in regulating various developmental processes. Its dysfunction can lead to severe disorders, highlighting the importance of continued research in this field.
Source	Rabbit
Specificity	The PAX8 antibody is capable of detecting the overall expression levels of endogenous PAX8. To produce a related piece of content, the text could be rewritten as follows: The total amount of PAX8 present within a sample can be detected using the PAX8 antibody, which is able to recognize endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Dog
Antigen	PAX8
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	60 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. A highly similar content can be generated by restructuring the original text in a different format, but still conveying the same information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is advisable to avoid subjecting the product to repeated freeze/thaw cycles which may compromise its quality. It is important to adhere to these storage guidelines to ensure the product retains its effectiveness and potency.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Tissue specificity	Expressed in the excretory system, thyroid gland and Wilms tumors.
Celluar localization	Nucleus;
UniPort	Q06710