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Rabbit Anti-PKNOX1 Polyclonal Antibody#abs132986

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Description

Catalog-specification	Delivery time	USD price
abs132986-100ug	1-2 Weeks	301.0
abs132986-50ug	1-2 Weeks	201.0

Overview
catalog	abs132986
Other names	The human homeobox containing protein, also known as PBX/knotted homeobox 1, is a transcription factor that plays a key role in embryonic development and hematopoiesis. Also referred to as homeobox protein PKNOX1 or Pbx regulating protein 1, this protein is essential for the normal function of different organs and tissues in the body. Another important player in cell development, Homeobox protein PREP-1, has also been identified to interact with PKNOX1. The PBX/knotted 1 homeobox 1 gene, or Pknox1, is responsible for the formation of the protein that regulates the activity of other genes and controls cell growth and differentiation. In humans, mutations in this gene have been associated with developmental disorders, including urinary tract malformations and intellectual disability. Similarly, the absence of PREP-1 has been linked to developmental abnormalities and lethality in mice. In summary, these homeobox proteins play vital roles in the regulation of gene expression and subsequent cell development. Dysfunction in their activity can lead to serious consequences in human health and development. Better understanding of their mechanisms and interactions can potentially lead to the development of new therapies for various genetic disorders.
Source	Rabbit
Specificity	The detection of endogenous levels of total PKNOX1 can be achieved using the PKNOX1 antibody. A highly similar content can be generated by rearranging the information in the original text as follows: The PKNOX1 antibody is capable of detecting total PKNOX1 at its natural levels within the organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Sheep;Dog;Horse;Bovine;
Antigen	PKNOX1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is advised to keep the product stored at a temperature of -20 °C for a period of one year. To maintain its quality, it is important to avoid subjecting it to repeated freeze and thaw cycles.
Storage buffer	：IgG，（pH 7.4），150mM，0.02%。50%。
Target
Tissue specificity	Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow.
Celluar localization	Nucleus;
UniPort	P55347