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Rabbit Anti-PDCD6 Polyclonal Antibody#abs137455

Description

Catalog-specification	Delivery time	USD price
abs137455-100ug	1-2 Weeks	301.0
abs137455-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137455
Other names	AIP1, also known as ALG-2-interacting protein 1 or ALG2, is a protein that interacts with ALG-2, a calcium-binding protein. It is also referred to as ALIX, Apoptosis linked gene 2, Apoptosis-linked gene 2 protein, and Apoptosis Linked Gene 2 protein. Other aliases include FLJ42309, FLJ46208, Hp95, KIAA1375, MA 3, MA3, MGC111017, MGC119050, MGC9123, PDCD 6, Pdcd6, PDCD6_HUMAN, PEF 1B, PEF1B, Probable calcium binding protein ALG 2, Probable calcium binding protein ALG2, Probable calcium-binding protein ALG-2, Programmed cell death 6, Programmed cell death 6-interacting protein, Programmed cell death protein 6, PS 2, and PS2. The main role of AIP1 is its interaction with ALG-2, which is involved in various cellular processes, including apoptosis (programmed cell death). AIP1, through its interaction with ALG-2, modulates apoptosis and cell death pathways. This protein is also thought to play a role in calcium signaling and may be involved in the regulation of intracellular calcium levels. The exact function of AIP1 is still not fully understood, but it is believed to be important in mediating cell death processes. AIP1 is widely expressed in various tissues and cell types, suggesting its relevance in different biological contexts. In summary, AIP1, also known as ALG-2-interacting protein 1 or ALG2, is a protein that interacts with ALG-2 and is involved in apoptosis and calcium signaling. It has various aliases and is important in regulating cell death pathways.
Source	Rabbit
Specificity	The endogenous levels of total PDCD6 can be detected using the PDCD6 antibody. The antibody is specifically designed to recognize and bind to the PDCD6 protein. It enables researchers to study the natural expression levels of PDCD6 in biological samples. By measuring the total PDCD6 protein, valuable insights into its functions and regulations can be obtained. This detection method is useful in various research areas, including cell biology, biochemical analysis, and disease studies.
Species Reactivity	Human
Predictive reaction species	Rabbit;Pig;Dog;Horse;Bovine
Antigen	PDCD6
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PDCD6.
MW	21 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).
Celluar localization	Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Nucleus;
UniPort	O75340