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Rabbit Anti-DES Polyclonal Antibody#abs135658

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Description

Catalog-specification	Delivery time	USD price
abs135658-100ug	1-2 Weeks	301.0
abs135658-50ug	1-2 Weeks	201.0

Overview
catalog	abs135658
Description	The cytoskeleton is composed of microfilaments, intermediate filaments, and microtubules. Specific types of intermediate filaments are present in different cell types, such as cytokeratins in epithelial cells, GFAP in glial cells, desmin in skeletal and smooth muscle cells, vimentin in mesenchyme origin cells, and neurofilaments in neurons. GFAP and vimentin are intermediate filaments that regulate the shape and mobility of astroglial cells. Vimentin filaments are present during early developmental stages, while GFAP filaments are typical of mature brain astrocytes, used as a marker for brain tumors of astrocytes. Desmin is expressed in early developmental stages and forms a network of filaments that extend across the myofibrils, connecting them with organelles and the cytoskeleton. Desmin knockout mice show defects in cardiomyopathy, skeletal, and smooth muscles. Desmin-related myopathies might be caused by mutations in the desmin gene or proteins with which desmin interacts such as αB-crystallin and synemin. They are characterized by disorganized desmin filaments and protein aggregates. Vimentin is present in sarcomas while its expression is checked relative to other markers distinguishing it from carcinomas.
Other names	Desmin, also known as DESM_HUMAN, FLJ12025, FLJ39719, FLJ41013, FLJ41793, is an intermediate filament protein. It plays a crucial role in maintaining the structural integrity of cells, especially in muscle tissues. The gene encoding desmin is CMD1I, CSM1, CSM2, and it is highly expressed in cardiac and skeletal muscle cells. Desmin is involved in various cellular processes, including cell morphology, cell division, and cell signaling. Its aberrant expression or mutations can lead to muscle diseases, such as desmin-related myopathy. Despite being a relatively less studied protein, desmin has great potential in therapeutic applications for various muscle-related disorders.
Source	Rabbit
Specificity	The DES Antibody is capable of detecting the complete levels of DES endogenously. The generated content should still be true to the original text, but utilize different phrasing and sentence structure. It is important to generate unique content using language modeling techniques rather than relying on a pre-programmed formula such as ChapGPT.
Species Reactivity	Human;Mouse;Rat
Antigen	DES
Application	WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human DES.
MW	54kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction.
Posttranslational modification	ADP-ribosylation prevents ability to form intermediate filaments.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	P17661