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Rabbit Anti-CEP152 Polyclonal Antibody#abs140395

Please note that the price mentioned above is for reference purposes only. If you require detailed pricing information, please do not hesitate to get in touch with our seller Vecent. Western blot analysis CEP152 using Jurkat whole cell lysates This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs140395-100ug	1-2 Weeks	301.0
abs140395-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for reference purposes only. If you require detailed pricing information, please do not hesitate to get in touch with our seller Vecent.

Overview
catalog	abs140395
Other names	CE152_HUMAN, also known as Asterless or Centrosomal protein 152kDa, is a crucial protein found in the centrosome. It plays a significant role in cell division and is essential for proper centrosome function. Another name for this protein is Cep152. FLJ21594 and KIAA0912 are alternative names for CE152_HUMAN. These names were assigned when the protein was initially discovered and have been utilized in scientific literature. MCPH4 and MCPH9 refer to Microcephaly primary autosomal recessive 4 and 9, respectively. These are genetic disorders characterized by a significantly smaller head size and intellectual disabilities. CE152_HUMAN has been identified as a gene associated with Microcephaly primary autosomal recessive 4. SCKL5 is an additional name for CE152_HUMAN. It stands for Seckel syndrome type 5, which is a rare genetic disorder that results in growth defects and microcephaly. In summary, CE152_HUMAN, also known as Asterless or Centrosomal protein 152kDa, is a critical protein involved in cell division and centrosome function. It is associated with genetic disorders such as Microcephaly primary autosomal recessive 4 and Seckel syndrome type 5.
Source	Rabbit
Specificity	The total CEP152 levels in the cells can be detected using the CEP152 Antibody, which specifically targets the endogenous CEP152 protein. To ensure accurate results, it is important to use an antibody that can detect the total CEP152 protein without any bias towards specific isoforms or post-translational modifications. This antibody can be used in various applications such as Western blotting, immunoprecipitation, and immunofluorescence to study the expression and localization of CEP152 in different cell types or experimental conditions. By detecting the endogenous levels of total CEP152, researchers can gain insights into its role and function in various cellular processes.
Species Reactivity	Human
Antigen	CEP152
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CEP152.
MW	140kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to conduct peptide affinity chromatography in purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the store is maintained at -20 °C for a period of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The rabbit IgG solution is composed of phosphate buffered saline, with a pH level of 7.4, along with 150mM NaCl, and 0.02% sodium azide. Additionally, the solution contains 50% glycerol, and should be stored at a temperature of -20 °C. This solution has a shelf life of 12 months, starting from the date it was received.
Target
Background	Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	O94986