Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PGE Synthase Polyclonal Antibody#abs138112

Please note that the price given here is only for your reference. If you need more information regarding the actual price, please contact our seller Vecent. Western blot analysis PGE synthase using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs138112-100ug	1-2 Weeks	301.0
abs138112-50ug	1-2 Weeks	201.0

Please note that the price given here is only for your reference. If you need more information regarding the actual price, please contact our seller Vecent.

Overview
catalog	abs138112
Other names	Microsomal glutathione S transferase 1 like 1, also known as MGST1L1 or MGST IV, belongs to the family of glutathione S-transferases (GSTs). It is encoded by the gene MGC10317 and is involved in various cellular processes. One of the functions of MGST1L1 is its role as a microsomal prostaglandin E synthase 1 (mPGES-1). It catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), which is an important mediator of inflammation and pain. Additionally, MGST1L1 has been implicated in apoptosis regulation. It is referred to as p53 induced apoptosis protein 12 (PIG12) or p53-induced gene 12 protein (TP53I12) because its expression is induced by the tumor suppressor protein p53. PIG12 is involved in the p53-mediated apoptotic pathway, which plays a critical role in suppressing tumor growth. Overall, MGST1L1 plays multiple roles in cellular processes, including the detoxification of electrophilic compounds through its GST activity, the synthesis of PGE2 as mPGES-1, and its involvement in p53-mediated apoptosis regulation. Understanding its functions and regulation can provide insights into potential therapeutic targets for various diseases, including cancer and inflammation.
Source	Rabbit
Specificity	The PGE synthase Antibody is capable of recognizing total PGE synthase at endogenous levels. This means that it can detect the presence of PGE synthase within an organism without the need for additional stimulation or treatments. It is important to note that this antibody can only detect total PGE synthase and not specific subtypes or isoforms. Nevertheless, it is a valuable tool for research and diagnostic purposes related to PGE synthase biology.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	PGE synthase
Application	，：WB 1:1000-3000，IHC 1:50-200，ELISA（）1:20,000-1:40,000。，。。（WB），1:10001:3000；（IHC），1:501:200；（ELISA），，1:20,0001:40,000。，。
Immunogen	A human PGE synthase derived peptide has been synthesized that closely mimics its original structure. The synthesized peptide is highly similar to the natural human protein and preserves its biological activity. Through its creation, this synthesized peptide offers a valuable tool for studying the function and regulation of human PGE synthase. By rearranging the content of the original text, we can see how this synthesized peptide is a promising avenue for further research into the important role that human PGE synthase plays in various cellular processes.
MW	17 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. The resulting product was highly purified and suitable for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
Tissue specificity	By p53/TP53.
Celluar localization	Endoplasmic reticulum;Nucleus;
UniPort	O14684