Phospho-TOPBP1 (Ser1159) Rabbit Polyclonal Antibody#abs140346
Please note that the price provided above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis TOPBP1 (Phospho-Ser1159) using PMA treated Jurkat whole cell lysates This product is for research use only,...
Description
| Catalog-specification | Delivery time | USD price |
abs140346-100ug | 1-2 Weeks | 301.0 |
abs140346-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.
| Overview | |
catalog | abs140346 |
| Other names | 1. DNA topoisomerase 2-binding protein 1, also known as DNA topoisomerase II binding protein 1 or TOPBP1, is a crucial protein involved in DNA replication and repair. 2. This protein, encoded by the KIAA0259 gene, plays a pivotal role in coordinating the functions of DNA topoisomerase II-beta. 3. TOPBP1 acts as an essential mediator of the DNA damage response and is involved in cell cycle control. 4. The binding of TOPBP1 to DNA topoisomerase II-beta regulates its activity and ensures proper DNA unwinding during replication and transcription processes. 5. TOPBP1 is not only implicated in DNA metabolism but also plays a significant role in maintaining genomic stability and preventing the accumulation of DNA damage. 6. Interestingly, this protein has been identified as a hypothetical protein, suggesting that further research is needed to fully elucidate its biological functions. 7. Given its critical role in DNA maintenance and repair, TOPBP1 remains a promising target for studying various diseases, including cancer and genetic disorders. 8. In conclusion, DNA topoisomerase 2-binding protein 1 is an essential protein that interacts with DNA topoisomerase II-beta, contributing to the regulation of DNA replication and repair processes. Further research on TOPBP1 will unveil its precise mechanisms and potential therapeutic applications. |
| Source | Rabbit |
| Specificity | The phosphorylation of TOPBP1 at Ser1159 is crucial for the detection of endogenous levels of TOPBP1 by the TOPBP1 (Phospho-Ser1159) Antibody. This antibody specifically recognizes TOPBP1 when it is phosphorylated at Ser1159. To effectively detect TOPBP1, it is essential that the antibody targets this specific phosphorylation site. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Rabbit;Sheep;Dog;Bovine;Horse; |
| Antigen | TOPBP1 |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | Human TOPBP1 (Phospho-Ser1159) can be utilized to produce a synthetic peptide. It is crucial to create a highly similar content by rearranging the information provided in the original text. Let's avoid generating content using the techniques employed by ChatGPT and focus on delivering a speech using a significantly different approach from that of a language model. |
| MW | 173 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | This purified rabbit serum antibody was obtained through affinity purification using phospho- and non-phospho-peptide affinity columns in sequential chromatography steps. The resulting content is highly similar to the original text information, but rearranged for clarity. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). |
| Tissue specificity | Highly expressed in heart, brain, placenta, lung and kidney. |
| Posttranslational modification | Phosphorylated on serine and threonine residues in response to X-ray irradiation.Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination. |
| Celluar localization | Cytoskeleton;Nucleus; |
| UniPort | Q92547 |
Western blot analysis TOPBP1 (Phospho-Ser1159) using PMA treated Jurkat whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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