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Rabbit Anti-TSH3 Polyclonal Antibody#abs139572

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Description

Catalog-specification	Delivery time	USD price
abs139572-100ug	1-2 Weeks	301.0
abs139572-50ug	1-2 Weeks	201.0

Overview
catalog	abs139572
Other names	Are you familiar with KIAA1474? It's also known as Teashirt homolog 3 or TSH3. Another name for it is TSHZ3, and it's also referred to as Zinc finger protein 537. This protein is an important factor in many cellular processes, and it has been the subject of extensive research. Understanding the role of KIAA1474 in the body could lead to important advances in medicine and biology. So, it's worth paying attention to this fascinating protein!
Source	Rabbit
Specificity	The detection ability of the TSH3 Antibody is focused on identifying total TSH3 levels present within the body's natural state. By rearranging the given content, a similar statement can be formed: "Total TSH3 levels are effectively identified by the TSH3 Antibody, which is capable of detecting the endogenous quantities in the body."
Species Reactivity	Human
Predictive reaction species	Chicken;Horse;
Antigen	TSH3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TSH3.
MW	119 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was utilized to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Securely keep the item for a duration of one year below -20 °C to ensure optimal storage conditions. It is crucial to prevent subjecting the item to multiple cycles of freezing and thawing.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it is recommended to store it at a temperature of -20°C for up to 12 months from the date of receipt.
Target
Background	Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).
Tissue specificity	Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656).
Celluar localization	Nucleus;
UniPort	Q63HK5