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Rabbit Anti-IGF1 Polyclonal Antibody#abs131492

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Description

Catalog-specification	Delivery time	USD price
abs131492-50ug	1-2 Weeks	201.0
abs131492-100ug	1-2 Weeks	301.0

Overview
catalog	abs131492
Description	The insulin-like growth factors have a strong resemblance to insulin in both structure and function, but they possess considerably higher growth-promoting activity. These factors have been identified in plasma and are believed to play a regulatory role in glycogen synthesis and [1-14C]-2-deoxy-D-glucose transport in osteoblasts. In particular, they have been shown to stimulate glucose transport in bone-derived osteoblastic cells in rats, known as PyMS cells. Compared to insulin, they are much more effective at lower concentrations with respect to glycogen and DNA synthesis as well as enhancing glucose uptake. These observations suggest that insulin-like growth factors may be an important factor in regulating glucose metabolism and bone growth.
Other names	Insulin-like growth factor 1 (IGF1) is also known as somatomedin C. It plays a crucial role in promoting growth and development in the human body. IGF1 acts as a mediator of the effects of growth hormone (GH) and is involved in various biological processes. There are different isoforms of IGF1, including IGF IA, IGF IB, and IGF-I. These isoforms exhibit slight variations in their structure and function. IGF1 is encoded by the IGF1 gene and is conserved across different species. One notable form of IGF1 is insulin-like growth factor IA (IGFIA) and insulin-like growth factor IB (IGFIB). These variants possess similar characteristics to IGF1 and contribute to its overall functions. IGF1 is known to regulate cell growth, proliferation, and differentiation. It acts on various target tissues, such as bones, muscles, and organs, promoting their development and maintenance. Additionally, IGF1 has an anabolic effect on muscle tissue, enhancing protein synthesis and muscle growth. Another molecule related to IGF1 is mechano growth factor (MGF). It is a peptide variant of IGF1 that is specifically generated in response to muscle damage or mechanical stress. MGF plays a crucial role in muscle repair and regeneration, ensuring optimal muscle function. Overall, IGF1 and its isoforms, including IGFIA, IGFIB, and IGF-I, along with MGF, play vital roles in regulating growth, development, and tissue repair processes in the human body. Their functions are essential for maintaining overall health and wellbeing.
Source	Rabbit
Specificity	The detection of endogenous levels of total IGF1 can be accomplished using IGF1 antibody. This antibody is specifically designed to recognize and bind to IGF1 molecules present in the biological system. By utilizing this antibody, researchers can accurately measure the total amount of IGF1, allowing for further studies on its role and function in various physiological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep
Antigen	IGF1
Application	The recommended dilutions for WB are between 1:500 to 1:2000, for IHC are between 1:50 to 1:200, and for ELISA using peptide are between 1:20000 to 1:40000. It is important to follow these dilutions in order to obtain accurate results for your experiments. By using appropriate dilutions, you can optimize the sensitivity and specificity of your assays. So, be sure to carefully consider the dilution range and use the appropriate one for your assays in order to achieve valid data.
Immunogen	A synthesized peptide derived from human IGF1.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P05019