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Rabbit Anti-AATF Polyclonal Antibody#abs133755

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Description

Catalog-specification	Delivery time	USD price
abs133755-100ug	1-2 Weeks	301.0
abs133755-50ug	1-2 Weeks	201.0

Overview
catalog	abs133755
Other names	The AATF gene, also known as CHE1, codes for the apoptosis antagonizing transcription factor. This protein plays a crucial role in cell survival by inhibiting apoptosis. It is also involved in the regulation of cell cycle progression and DNA repair. The AATF protein interacts with several other proteins, including RB1, to regulate gene expression. It has been shown to be overexpressed in certain cancers, indicating its potential as a therapeutic target. In addition, the AATF protein is involved in the maintenance of stem cell pluripotency and differentiation. It has been implicated in the development of the nervous system and in response to stress. Overall, the AATF protein plays a critical role in cellular processes and has implications in both health and disease. A better understanding of its function could lead to the development of novel treatments for various disorders.
Source	Rabbit
Specificity	The AATF Antibody is capable of detecting total AATF levels in the body. This antibody is designed to specifically identify endogenous AATF, which is naturally produced within the body. By targeting this protein, the AATF Antibody can provide valuable insight into various biological processes that involve AATF regulation. Overall, this antibody is an essential tool for researchers looking to investigate the role of AATF in different physiological pathways.
Species Reactivity	Human;Mouse;Rat
Antigen	AATF
Application	The dilution range for Western Blot (WB) is 1:500 to 1:1000. For Immunofluorescence (IF) or Immunocytochemistry (ICC), the dilution range is 1:100 to 1:500. When it comes to ELISA using peptides, the recommended dilution range is 1:20000 to 1:40000.
Immunogen	A synthesized peptide.
MW	63 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography purification of the antiserum. The resulting product was highly refined and concentrated to ensure that it met strict quality standards.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure longevity, it's important to store the product at a temperature of -20°C for a period of one year. Please take care to avoid any instances of repeated freeze and thaw cycles, as this can significantly impact the product's quality.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in phosphate buffered saline with a pH of 7.4. Additionally, the solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is worth noting that the stability of Rabbit IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Tissue specificity	Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
Posttranslational modification	Hyperphosphorylated during the G1/S phase transition.
Celluar localization	Golgi apparatus;Nucleus;
UniPort	Q9NY61