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Rabbit Anti-IL27RA Polyclonal Antibody#abs139680

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Description

Catalog-specification	Delivery time	USD price
abs139680-100ug	1-2 Weeks	301.0
abs139680-50ug	1-2 Weeks	201.0

Overview
catalog	abs139680
Other names	The IL-27 receptor subunit alpha, also known as Cytokine receptor-like 1 or CRL1, is a class I cytokine receptor that plays a crucial role in regulating immune responses. This receptor is encoded by the IL27RA gene and is part of the interleukin-27 receptor complex. Other names for this receptor include IL-27R subunit alpha, IL-27R-alpha, IL27R alpha, IL27R, Interleukin 27 receptor alpha chain precursor, Interleukin 27 receptor, Protein CRL1, T cell cytokine receptor type 1, TCCR, Type 1 T cell cytokine receptor, Type I T-cell cytokine receptor, WSX-1, WSX1, and ZcytoR1. The IL-27 receptor subunit alpha binds to the cytokine IL-27, which is produced by activated antigen-presenting cells. This interaction stimulates the production of cytokines and chemokines, which play a role in immune cell recruitment and activation. Mutations in the IL-27RA gene have been associated with autoimmune diseases, and blocking IL-27 signaling has been shown to be effective in treating certain autoimmune diseases in animal models. Therefore, understanding the role of the IL-27 receptor subunit alpha in regulating immune responses may lead to the development of new therapies for autoimmune diseases.
Source	Rabbit
Specificity	The total IL27RA levels can be measured using the IL27RA Antibody, which is capable of detecting endogenous levels of IL27RA.
Species Reactivity	Human
Predictive reaction species	Pig
Antigen	IL27RA
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL27RA.
MW	69 kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum underwent purification by means of peptide affinity chromatography. It was a meticulous process that resulted in a highly refined product.
Clonality	Polyclonal Antibody
Stability & Storage	One should keep the product in a freezer at a temperature of -20 °C for a period of one year. It is advisable to avoid any instances of repeated freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Tissue specificity	Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
Celluar localization	Plasma Membrane;
UniPort	Q6UWB1