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Rabbit Anti-IL28A Polyclonal Antibody#abs139679

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Description

Catalog-specification	Delivery time	USD price
abs139679-100ug	1-2 Weeks	301.0
abs139679-50ug	1-2 Weeks	201.0

Overview
catalog	abs139679
Other names	IL-28A, also known as IFN-lambda-2 or Interferon lambda-2, is a cytokine that plays a key role in the immune system's response to infection. It is part of the family of interferons and is closely related to IL-28B and IL-29. IL-28A is also sometimes referred to as ZCYTO20, or simply Interleukin-28A. Recent research has shown that IL-28A has potent antiviral activity against a wide range of pathogens, including influenza virus, hepatitis C virus, and herpes simplex virus. It achieves this by stimulating the immune system to produce a range of antiviral proteins, which help to destroy infected cells and prevent the spread of the virus. IL-28A is primarily produced by immune cells such as dendritic cells, macrophages, and T cells in response to viral infections. It has also been shown to have anti-tumor effects, suggesting that it may be useful in the treatment of certain types of cancer. Overall, IL-28A is a critical component of the immune system's response to viral infections and is a promising target for the development of new antiviral and anti-cancer therapies.
Source	Rabbit
Specificity	The endogenous levels of total IL28A can be detected using the IL28A Antibody. By employing this antibody, researchers are able to determine the presence and quantity of IL28A in biological samples. This allows for a comprehensive understanding of IL28A expression and its potential implications in various physiological and pathological processes.
Species Reactivity	Human
Antigen	IL28A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL28A.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for purification. A highly similar statement can be generated by rephrasing the original content, but it should retain the same meaning and convey the same information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store for one year at a temperature of -20 °C, making sure to prevent repeated freeze/thaw cycles. It is crucial to follow these storage guidelines for optimal preservation.
Storage buffer	The rabbit IgG is formulated in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product should be stored at -20 °C. It has a shelf life of 12 months from the date of receipt.
Target
Background	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Tissue specificity	By viral infections or double-stranded RNA.
Celluar localization	Extracellular region or secreted;
UniPort	Q8IZJ0