Rabbit Anti-TTF2 Polyclonal Antibody #abs130545

abs130545-50ug

1-2 Weeks

201

abs130545-100ug

1-2 Weeks

301

Description

This particular gene does not contain introns and belongs to the forkhead family of transcription factors. It is distinguished by its unique forkhead domain and is responsible for regulating thyroid transcriptional activity, which is crucial for normal thyroid gland development. Mutations in this gene have been linked to congenital hypothyroidism and thyroid dysgenesis with cleft palate. Based on its map location, this gene may also be associated with squamous cell carcinoma and hereditary sensory neuropathy type I.

Other names

Forkhead-like 15 (FKHL 15), also known as forkhead box E1 and E2 (FOX E1, FOX E2), is a protein that belongs to the forkhead box family of transcription factors. It is encoded by the FOXE1 and FOXE2 genes. FKHL 15 plays a critical role in regulating various biological processes, including development, differentiation, and proliferation.
FKHL 15 is a homolog of the Drosophila forkhead protein and is highly conserved across species. It is expressed in a variety of tissues, including thyroid, lung, tongue, and skin. In the thyroid gland, it is known as thyroid transcription factor 2 (TTF 2) or TITF 2. It is involved in the regulation of thyroid-specific genes during thyroid development and function.
FKHL 15 is also implicated in the development of various cancers, including thyroid cancer and breast cancer. Dysregulation of FKHL 15 expression and function has been linked to tumor growth and progression.
Overall, FKHL 15 is a versatile transcription factor that plays crucial roles in several biological processes and diseases. Its regulation and function warrant further investigation for the development of potential therapeutic targets.

Source

Rabbit

Specificity

TTF2 Antibody detects endogenous levels of TTF2

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human TTF2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

Ensure the storage temperature is maintained at -20 °C for a duration of one year, while taking precautions to prevent repeated freeze/thaw cycles.

Storage buffer

Our Rabbit IgG solution comes in a phosphate buffered saline, pH 7.4 with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It should be stored at a temperature of -20 °C and is stable for up to 12 months from the date of receipt. Please ensure that you follow the proper storage instructions to maintain the integrity of the solution.

Target

Background

This transcription factor is known to bind to consensus sites on a range of gene promoters, effectively activating their transcription. Its function is crucial in the proper formation of the palate, likely by regulating the expression of the MSX1 and TGFB3 genes, which are direct targets of this factor. Additionally, its involvement in the morphogenesis of the thyroid gland has been established. This factor may also indirectly influence cell growth and migration through its effect on regulating the expression of WNT5A.

Tissue specificity

Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.

Posttranslational modification

Phosphorylated.

Celluar localization

Nucleus;

UniPort

O00358