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Rabbit Anti-CaMKIbeta Polyclonal Antibody#abs140385

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Description

Catalog-specification	Delivery time	USD price
abs140385-100ug	1-2 Weeks	301.0
abs140385-50ug	1-2 Weeks	201.0

Overview
catalog	abs140385
Other names	CaM kinase IB, also known as Calcium/calmodulin dependent protein kinase type 1B or CaM KI beta, is an enzyme that is encoded by the PNCK gene in humans. This enzyme belongs to the CaM kinase family and is involved in the regulation of various cellular processes such as muscle contraction, neurotransmitter release, and gene expression. CaM kinase IB is activated by the binding of calcium ions and calmodulin, which leads to its autophosphorylation and subsequent activation of downstream targets. CaM kinase I beta is a highly conserved protein that plays a crucial role in many physiological functions. It is widely expressed in various tissues, including the brain, heart, and skeletal muscle. CaMKI beta has been shown to regulate the activity of ion channels, transcription factors, and synaptic proteins, thereby influencing synaptic plasticity and memory formation. Moreover, CaMKI beta is involved in the regulation of glucose metabolism and insulin secretion, making it an important target in the treatment of diabetes. In conclusion, CaM kinase IB is a versatile enzyme that is involved in many aspects of cellular signaling and regulation. Its diverse functions and importance in various physiological processes make it a promising therapeutic target for the treatment of various diseases.
Source	Rabbit
Specificity	The CaMKIbeta Antibody can identify the overall levels of CaMKIbeta that are present within the body. This means that it is able to detect the amounts of CaMKIbeta that occur naturally, without any alterations or modifications. To create content that is highly similar, you could rearrange the words and phrases in the original text to say something like: Detecting endogenous CaMKIbeta levels is made possible by using the CaMKIbeta Antibody, which can identify the total amount of CaMKIbeta that is present in the body. This antibody is able to detect the natural levels of CaMKIbeta, without any changes or manipulations.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	CaMKIβ
Application	The recommended dilution for Western blot is 1:1000, while for immunofluorescence/immunocytochemistry, a dilution range of 1:100-1:500 is suggested. For ELISA using peptide, the recommended dilution is between 1:20000-1:40000. It is important to note that these dilutions may vary depending on the specific experiment and should be optimized accordingly.
Immunogen	A human CaMKIbeta-derived synthesized peptide has been developed to closely resemble the original text information. It has been meticulously designed using the original content as a foundation.
MW	38kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure the highest quality and effectiveness, this process was carefully carried out to remove any impurities and enhance the potency of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this may compromise its quality and efficacy. Take adequate precautions to maintain the recommended storage conditions and maximize the shelf life of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).
Posttranslational modification	Phosphorylated by CAMKK1.
Celluar localization	Nucleus;
UniPort	Q6P2M8