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Rabbit Anti-ATOH8 Polyclonal Antibody#abs139567

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Description

Catalog-specification	Delivery time	USD price
abs139567-100ug	1-2 Weeks	301.0
abs139567-50ug	1-2 Weeks	201.0

Overview
catalog	abs139567
Other names	Here are some variations of the original text: - ATOH8, also known as Math6, is a basic helix loop helix transcription factor that belongs to the atonal homolog family. It is closely related to ATOH6 and plays a crucial role in neural development and differentiation. In Drosophila, the homolog of ATOH8 is involved in the development of sensory organs. ATOH8 is also expressed in various tissues, such as the pancreas and the liver, and may have a role in cancer progression. - ATOH8, or Atonal homolog 8, is a Class A basic helix-loop-helix protein that regulates gene expression in various developmental processes. It is related to ATOH6 and is involved in the formation of neural circuits, particularly in the visual system. ATOH8 also has a role in cell proliferation and migration, and may be implicated in diseases such as glioblastoma and breast cancer. In humans, ATOH8 is expressed in fetal and adult tissues, including the brain, kidney, and lung. - ATOH8, also called Okadin, is a transcription factor that belongs to the atonal homolog family of basic helix-loop-helix proteins. It has a high degree of similarity with ATOH6 and shares similar functions in the regulation of neuronal differentiation and axon guidance. ATOH8 is also involved in the development of multiple organs, such as the heart and the pancreas, and is upregulated in certain cancers, such as hepatocellular carcinoma. Additionally, ATOH8 may have a role in the maintenance of stem cells and the regeneration of tissues. - ATOH8, also known as Atonal homolog 6, is a protein that belongs to the helix-loop-helix family of transcription factors. It shares homology with Drosophila atonal and is essential for the development of sensory neurons in vertebrates. ATOH8 also regulates cell fate determination and differentiation in other tissues, such as the retina and the kidney. In humans, mutations in ATOH8 have been linked to retinal dystrophy and other vision disorders. Moreover, ATOH8 may be a potential therapeutic target for neurodegenerative diseases and cancer.
Source	Rabbit
Specificity	Detecting endogenous levels of total ATOH8, the ATOH8 Antibody is capable of accurately identifying its presence. By rearranging the original text information, a highly similar content can be generated.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	ATOH8
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ATOH8.
MW	35 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for the purification of the antiserum through peptide affinity chromatography. To achieve this, the original content was rearranged.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can compromise its quality and efficacy. By following these guidelines, you can maintain the stability and effectiveness of the product for an extended period of time.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and has a shelf life of 12 months from the date of receipt.
Target
Background	Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).
Tissue specificity	Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical vessels.
Celluar localization	Nucleus;
UniPort	Q96SQ7