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Rabbit Anti-CXCL13 Polyclonal Antibody#abs139438

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Description

Catalog-specification	Delivery time	USD price
abs139438-100ug	1-2 Weeks	301.0
abs139438-50ug	1-2 Weeks	201.0

Overview
catalog	abs139438
Other names	B-cell-attracting chemokine 1, also known as BCA-1 or CXCL13, is a chemokine that plays a crucial role in immune cell recruitment and activation. Its function is to attract B lymphocytes to specific sites within the body, promoting their migration and localization. CXCL13 is a member of the C-X-C chemokine family and is produced by various cell types, including stromal cells, follicular dendritic cells, and macrophages. This chemokine was initially identified for its role in Burkitt's lymphoma, where it acts as a ligand for the Burkitt's lymphoma receptor-1. However, its effects are not limited to cancer cells, as it also plays a vital role in normal immune responses. CXCL13 helps create specialized microenvironments called germinal centers, where B cells undergo maturation, proliferation, and differentiation. The expression of CXCL13 can be induced by various factors, such as pro-inflammatory cytokines, bacterial or viral infections, and tissue damage. It is involved in the recruitment of B cells during immune responses against infections, autoimmune diseases, and chronic inflammation. Additionally, CXCL13 has been implicated in the pathogenesis of several conditions, including rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. Understanding the mechanisms behind B cell recruitment and homing is crucial for developing targeted therapies to modulate immune responses. By manipulating CXCL13 signaling, it may be possible to regulate B cell migration and activation in specific tissues, leading to improved treatment strategies for various immune-related disorders. Further research into the precise functions and regulation of CXCL13 is ongoing, with the aim of uncovering new therapeutic opportunities in the field of immunology.
Source	Rabbit
Specificity	Endogenous levels of total CXCL13 can be detected using the CXCL13 Antibody.
Species Reactivity	Human
Antigen	CXCL13
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CXCL13.
MW	13 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly concentrated and pure product was obtained as a result of this process.
Clonality	Polyclonal Antibody
Stability & Storage	，-20°C，。，。
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Tissue specificity	Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Celluar localization	Extracellular region or secreted;
UniPort	O43927