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Rabbit Anti-GABARAP Polyclonal Antibody#abs136931

Description

Catalog-specification	Delivery time	USD price
abs136931-100ug	1-2 Weeks	301.0
abs136931-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136931
Description	Gamma-aminobutyric acid A receptors
Other names	FLC 3B; FLC3B; FLJ25768; GABA(A) receptor associated protein; GABA(A) receptor-associated protein; GABARAP a; GABARAP; Gamma aminobutyric acid receptor associated protein; Gamma-aminobutyric acid receptor-associated protein; GBRAP_HUMAN; MGC120154; MGC120155; MM 46; MM46; - These are various names associated with a protein called GABARAP. It is an important protein that is involved in the functioning of GABA(A) receptors, which are receptors for the neurotransmitter gamma-aminobutyric acid (GABA). GABARAP plays a crucial role in modulating the activity of GABA(A) receptors and is essential for maintaining the balance of inhibitory neurotransmission in the brain. It is also involved in various cellular processes, including autophagy, which is the process of degrading and recycling cellular components. GABARAP is expressed in various tissues and its dysfunction has been implicated in several neurological disorders, including epilepsy and schizophrenia. Further research on GABARAP and its functions may provide valuable insights into the development of new therapeutic strategies for these disorders.
Source	Rabbit
Specificity	Endogenous levels of total GABARAP can be detected using the GABARAP antibody. Generate a highly similar content by rearranging the above information:
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;
Antigen	GABARAP
Application	The dilution ratios for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. These dilution ratios specify the concentration of the reagents used in these assays to ensure accurate and reliable results. By adjusting the dilution ratios within the recommended ranges, researchers can effectively optimize the assays for their specific experimental conditions. It is important to note that these dilution ratios may vary depending on the specific antibodies, antigens, and detection methods used in each assay.
Immunogen	A synthesized peptide derived from human GABARAP.
MW	13kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used for peptide affinity chromatography in order to purify the antiserum. Please rearrange the given content to generate highly similar content, while ensuring it is based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage at -20 °C is recommended to maintain the integrity of the product. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Tissue specificity	Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Posttranslational modification	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.
Celluar localization	Cytoskeleton;Cytosol;Endoplasmic reticulum;Golgi apparatus;Lysosome;Plasma Membrane;
UniPort	O95166