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Rabbit Anti-MKP-2 Polyclonal Antibody#abs140467

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Description

Catalog-specification	Delivery time	USD price
abs140467-100ug	1-2 Weeks	301.0
abs140467-50ug	1-2 Weeks	201.0

Overview
catalog	abs140467
Other names	Dual specificity protein phosphatase 4, also known as DUSP4 or HVH2, is an enzyme that plays a crucial role in regulating cellular signaling pathways. It belongs to the family of dual specificity phosphatases, which means it can dephosphorylate both tyrosine and serine/threonine residues on target proteins. The primary function of DUSP4 is to regulate the activity of mitogen-activated protein kinases (MAPKs). MAPKs are key components of several intracellular signaling pathways that are involved in cell growth, differentiation, survival, and apoptosis. DUSP4 acts as a negative regulator of MAPKs by dephosphorylating and inactivating them. DUSP4 is also involved in the regulation of other cellular processes, such as DNA damage response, cell cycle progression, and gene expression. It has been shown to be altered in several types of cancer, suggesting that it may play a role in the development and progression of these diseases. Overall, DUSP4 is an important enzyme that plays a critical role in maintaining cellular homeostasis and preventing the development of various diseases. Understanding its function and regulation could provide new insights into the development of novel therapeutic strategies for the treatment of human diseases.
Source	Rabbit
Specificity	The detection of endogenous levels of total MKP-2 is possible using the MKP-2 Antibody. The antibody is specifically designed to recognize and bind to MKP-2 protein, enabling the accurate determination of its presence in biological samples. This detection method provides valuable insights into the overall levels of MKP-2 in a given system. By utilizing the MKP-2 Antibody, researchers can investigate the role and regulation of MKP-2 in various physiological and pathological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	MKP-2
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MKP-2.
MW	44kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum. The purification process involved using the resin to separate and isolate the desired components from the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C，/。
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Posttranslational modification	Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.
Celluar localization	Nucleus;
UniPort	Q13115