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Rabbit Anti-CD247 Polyclonal Antibody#abs136308

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of Jurkatcell lines, using CD247 antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs136308-100ug	1-2 Weeks	301.0
abs136308-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs136308
Description	The specific protein that this gene encodes is known as T-cell receptor zeta. When combined with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, T-cell receptor-CD3 complex is formed. T-cell receptor zeta plays a critical role in linking antigen recognition to multiple intracellular signal-transduction pathways. If the antigen expression is low, it can lead to a weakened immune response. This gene has two different isoforms due to alternative splicing of transcripts. Both isoforms have distinct features and functions. These findings were reported in the RefSeq database in July 2008.
Other names	5J0490543Rik; R18A401F440Ik; 088052WA; 247DC; CD247 antigen; Molecule Cd247; Cd3; Isoform of Cd3 antigen, zeta polypeptide CRA_b; Subunit of zeta of Cd3 antigen; Cd3-eta; Cd3H; Cd3Q; Cd3z; Polypeptide of zeta antigen (TiT3 complex); CD3Z_HUMAN; Cd3zeta; Zeta chain Cd3; MGC140430; T3 zeta chain of T cell receptor; Glycoprotein Cd3 zeta chain of T cell surface; Zeta subunit of T cell antigen receptor complex CD3; T3 zeta chain of T cell receptor; T cell surface glycoprotein CD3 zeta chain; Zeta chain of TCR; K TCR; Z TCR; Zeta TCR.
Source	Rabbit
Specificity	The endogenous levels of total CD247 can be detected using the CD247 Antibody. This antibody specifically targets CD247 protein and allows for the detection of its total amount in the sample. By using this antibody, researchers can accurately measure the levels of CD247, providing valuable information about its expression and potential implications in various biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	CD247
Application	The recommended dilution for Western blotting is 1:500 to 1:2000, while for immunohistochemistry it is 1:50 to 1:200, and for immunofluorescence/immunocytochemistry it is 1:100 to 1:500. For ELISA (using a peptide substrate), the suggested dilution is 1:20000 to 1:40000. To summarize, the dilutions for each application may vary slightly, and it's essential to optimize the dilution for your specific experiment.
Immunogen	A synthesized peptide derived from human CD247.
MW	16kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Posttranslational modification	Phosphorylated on Tyr residues after T-cell receptor triggering.
Celluar localization	Plasma Membrane;
UniPort	P20963