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Rabbit Anti-CCR3 Polyclonal Antibody#abs139725

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Description

Catalog-specification	Delivery time	USD price
abs139725-100ug	1-2 Weeks	301.0
abs139725-50ug	1-2 Weeks	201.0

Overview
catalog	abs139725
Other names	The CC chemokine receptor 3, also known as CCR-3, CD193, or Eotaxin receptor, is a protein expressed on the surface of certain immune cells, including eosinophils and macrophages. This receptor is important for the recruitment and activation of immune cells in response to inflammation and infection. It binds to C-C chemokines, such as eotaxin, and plays a role in the regulation of allergic responses and asthma. Other names for this receptor include CC-CKR-3, CKR3, and CMKB R3. Overall, CCR-3 is an essential component of the immune system and plays a critical role in the body's defense against pathogens and disease.
Source	Rabbit
Specificity	The endogenous levels of total CCR3 can be effectively detected using the CCR3 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	CCR3
Application	Here are some similar ways to express the information in the original text: - For Western blotting, a dilution of 1:1000 to 1:3000 is recommended, while for immunohistochemistry, a dilution of 1:200 should suffice. In ELISA assays using peptide antigens, the optimal dilution range is between 1:20000 and 1:40000. - To achieve strong and specific results in Western blot analysis, we suggest using a dilution of 1:1000 for high-concentration samples and 1:3000 for low-concentration samples. For immunohistochemistry staining, a dilution of 1:200 is optimal for most applications. When performing ELISA with peptide antigens, a dilution range of 1:20000-1:40000 is recommended to detect low levels of target protein. - If you're planning to perform Western blotting experiments, we recommend diluting your samples at a ratio of 1:1000 to 1:3000 for optimal results. Immunohistochemistry staining can be achieved most effectively using a 1:200 dilution. When working with peptide antigens in ELISA assays, it's best to use a dilution range of 1:20000 to 1:40000 to ensure the sensitivity and specificity of your assay. - When it comes to Western blotting, a good starting point for diluting your samples is between 1:1000 and 1:3000. For immunohistochemistry, a dilution of 1:200 is sufficient for most applications. For ELISA assays using peptide antigens, you'll want to use a dilution range of 1:20000 to 1:40000 to detect low levels of your target protein.
Immunogen	A synthesized peptide derived from human CCR3.
MW	41 kDa
Properties
Concentration	1mg/ml
purification	Through the process of peptide affinity chromatography, the antiserum was effectively purified using SulfoLink™ Coupling Resin. This technique allowed for a highly specific and targeted purification, ensuring that only the desired peptides were isolated and removed any potential contaminants. The resulting antiserum was of high purity and quality, making it suitable for a variety of research applications.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at a temperature of -20 °C for a period of one year. It is important to prevent the product from undergoing repeated cycles of freezing and thawing. This will help to preserve the efficacy and quality of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Tissue specificity	In eosinophils as well as trace amounts in neutrophils and monocytes.
Celluar localization	Plasma Membrane;
UniPort	P51677