Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CCR10 Polyclonal Antibody#abs139724

Please note that the price provided above is just for your reference. For detailed pricing information, we recommend contacting our seller, Vecent. However, it is important to generate unique content based on the original text information instead of simulating a chat conversation using ChapGPT....

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs139724-100ug	1-2 Weeks	301.0
abs139724-50ug	1-2 Weeks	201.0

Overview
catalog	abs139724
Other names	C-C chemokine receptor type 10, also known as CCR-10 or CC-CKR-10, is a G-protein coupled receptor (GPCR) that plays a significant role in cell signaling and immune response. It belongs to the chemokine receptor family and is encoded by the CCR10 gene in humans. This receptor is involved in the migration and activation of immune cells, particularly T cells and dendritic cells, during inflammation and immune surveillance. CCR-10 binds to specific chemokines, such as CCL27 and CCL28, and mediates their effects on cell recruitment and homing. Understanding the function and regulation of CCR-10 is essential for developing therapeutic strategies targeting immune-related diseases and inflammatory disorders.
Source	Rabbit
Specificity	The CCR10 Antibody is capable of detecting total CCR10 levels that occur naturally within the body. The antibody is designed to target this specific protein and can effectively identify it in various biological contexts. By using this tool, researchers can gain valuable insights into the functional role of CCR10 in different physiological processes. Overall, CCR10 Antibody is an essential tool for anyone seeking to explore the function of this protein in greater detail.
Species Reactivity	Human;Mouse
Antigen	CCR10
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CCR10.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly purified end product was obtained as a result of this process.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its integrity, it is recommended to store the item at a temperature of -20 °C for a duration of one year. The occurrence of multiple freeze/thaw cycles should be avoided.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in a solution containing phosphate buffered saline at pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This storage method ensures stability for a period of 12 months from the date of receipt.
Target
Background	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Tissue specificity	Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
Celluar localization	Plasma Membrane;
UniPort	P46092