Rabbit Anti-Pax-5 Polyclonal Antibody #abs130174

abs130174-50ug

1-2 Weeks

201

abs130174-100ug

1-2 Weeks

301

Description

The protein AX5 has been found to have multiple functions in the human body, playing important roles in key processes such as B-cell differentiation, neural development, and spermatogenesis. One of its key roles is in regulating the CD19 gene, which is specific to B-lymphoid cells. Studies have shown that AX5 interacts with the protein DAXX and binds to DNA as a monomer. Additionally, it has been found to bind to TLE4, which may have important implications for its role in neural development. Overall, these findings suggest that AX5 plays a complex and multifaceted role in the human body, with numerous potential downstream targets and pathways that may be influenced by its activity.

Other names

The B cell lineage specific activator is a crucial protein that plays a role in the regulation of B cell development and differentiation. Also known as the B cell specific transcription factor or BSAP, this transcription factor is encoded by the PAX5 gene. Other names for this protein include EBB-1, KLP, Paired box protein Pax-5, and paired box homeotic gene 5.
PAX5 is a highly conserved transcription factor that is expressed specifically in B cells. It is essential for the development and maturation of B cells, as it regulates genes involved in B cell differentiation, signaling, and activation. PAX5 binds to regulatory regions of target genes and activates or represses their expression, depending on the context.
PAX5 is also important in the maintenance of B cell identity, as it represses genes that are characteristic of other cell types. Loss of PAX5 or mutations in its DNA-binding domain can lead to the development of B-cell acute lymphoblastic leukemia or other B-cell malignancies.
In summary, the B cell lineage specific activator, or PAX5, is a transcription factor that is essential for the development and function of B cells. Its role in B cell differentiation and identity makes it an important target for research into B-cell malignancies and immunodeficiencies.

Source

Rabbit

Specificity

The detection of endogenous levels of total Pax-5 can be achieved by using the Pax-5 antibody. This antibody is specifically designed to recognize Pax-5 protein and enables researchers to analyze the expression of Pax-5 in a variety of cell types and tissues. By detecting total Pax-5, this antibody provides valuable insights into the regulation of gene expression and cellular differentiation. Highly sensitive and reliable, the Pax-5 antibody is a powerful tool for investigating the signaling pathways and molecular mechanisms involved in a wide range of biological processes.

Species Reactivity

Mouse;Human

Application

WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human Pax-5

Properties

Concentration

1mg/ml

Purification

Affinity-chromatography

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze-thaw cycles, as this can lead to a decrease in its efficacy and integrity over time.

Storage buffer

This product contains Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, with 150mM of NaCl, 0.02% of sodium azide and 50% of glycerol. It is recommended to store the product at -20 °C and it is stable for 12 months from the date of receipt. Make sure you follow the storage instructions to ensure the quality and effectiveness of the product.

Target

Background

CD19 gene regulation is a crucial aspect of B-cell differentiation and it also influences neural development and spermatogenesis. Its involvement in CD19 gene regulation supports the development of B-lymphoid-specific functions.

Tissue specificity

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Posttranslational modification

O-glycosylated.

Celluar localization

Cytosol;Nucleus;

UniPort

Q02548