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Rabbit Anti-MINK1 Polyclonal Antibody#abs140466

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Description

Catalog-specification	Delivery time	USD price
abs140466-100ug	1-2 Weeks	301.0
abs140466-50ug	1-2 Weeks	201.0

Overview
catalog	abs140466
Other names	MiNK, also known as Map4k6 or MINK1, is a member of the GCK family kinase. It is also referred to as MEK (MAP/ERK) kinase kinase 6 or MEKKK6. Other aliases include Misshapen like kinase 1, Misshapen NIKs Related kinase, and Misshapen/NIK related kinase. This protein, encoded by the MINK1 gene, is classified as a mitogen-activated protein kinase kinase kinase kinase 6. It is also known by its alternative names hMINK, MEK kinase kinase 6, MEK kinase kinase 6, MGC21111, MINK, RP23-122P1.6, Ysk2, and ZC3.
Source	Rabbit
Specificity	The MINK1 Antibody has the ability to recognize total MINK1 levels in the body. This means that it can detect the natural amounts of MINK1 present in cells, tissues, or fluids without any external intervention. If you are looking to study MINK1, this antibody can help provide accurate and reliable data.
Species Reactivity	Human
Predictive reaction species	Xenopus;Pig;Dog;Bovine;Horse
Antigen	MINK1
Application	For Western Blot analysis, a dilution of 1:1000 is recommended. When performing Immunofluorescence or Immunocytochemistry, a dilution range of 1:100 to 1:500 is suitable. For ELISA utilizing a peptide substrate, the recommended dilution range is 1:20000 to 1:40000. It is essential to adhere to the recommended dilutions for optimal results.
Immunogen	A synthesized peptide derived from human MINK1.
MW	150kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography. It was a highly effective method that resulted in the isolation of a pure and specialized product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this can impact its quality and effectiveness over time. By following these storage recommendations, you can help ensure that the product remains stable and effective for its intended use for as long as possible.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Tissue specificity	Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
Posttranslational modification	Autophosphorylated.
Celluar localization	Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	Q8N4C8