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Rabbit Anti-MRGX1 Polyclonal Antibody#abs135293

Please note that the price provided is for reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts from MCF-7 cells, using MRGX1 antibody. This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs135293-100ug	1-2 Weeks	301.0
abs135293-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference only. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs135293
Other names	MRGPRX1 is also known as MAS related gene MRGX1, MAS related GPR member X1, and SNSR4. It is a G protein-coupled receptor (GPCR).
Source	Rabbit
Specificity	Endogenous levels of total MRGX1 can be detected using the MRGX1 Antibody. To ensure accurate results, it is essential to utilize a highly similar content arrangement, reflecting the original text information.
Species Reactivity	Human
Antigen	MRGX1
Application	For Western blotting, a dilution of 1:500 to 1:1000 is recommended. When performing immunofluorescence or immunocytochemistry, dilute the primary antibody between 1:100 and 1:500. For ELISA assays using a peptide substrate, a dilution of 1:20000 to 1:40000 should be used. It's important to adjust the dilution accurately in order to obtain the best results for your specific experiment.
Immunogen	A synthesized peptide.
MW	36 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it needs to be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of Rabbit IgG is guaranteed for a duration of 12 months from the date of receipt.
Target
Background	This orphan receptor plays a potential role in the functioning of nociceptive neurons, possibly influencing the perception and modulation of pain. It may contribute to the regulation and development of nociceptors. Activation of this receptor by enkephalins, particularly BAM22 and BAM (8-22), leads to a significant and dose-dependent release of intracellular calcium. The calcium-signaling pathway involving G(alpha)q proteins is implicated in this process. Moreover, the antimalarial medication, chloroquine, can activate this receptor and potentially induce itchiness, independent of histamine.
Tissue specificity	Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Celluar localization	Plasma Membrane;
UniPort	Q96LB2