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Rabbit Anti-MTR1B Polyclonal Antibody#abs135296

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Description

Catalog-specification	Delivery time	USD price
abs135296-100ug	1-2 Weeks	301.0
abs135296-50ug	1-2 Weeks	201.0

Overview
catalog	abs135296
Other names	MT2 melatonin receptor, also known as Mel1b receptor or Mel1b melatonin receptor, is encoded by the Mtnr1b gene in humans. It belongs to the family of melatonin receptors and plays a crucial role in mediating the effects of melatonin, a hormone involved in regulating the sleep-wake cycle. The Mel1b receptor is primarily expressed in the brain, particularly in regions involved in circadian rhythm regulation, such as the suprachiasmatic nucleus (SCN). Activation of the Mel1b receptor by melatonin helps to synchronize the internal body clock with the light-dark cycle. Studies have shown that disruptions in Mel1b receptor signaling can lead to sleep disturbances and other circadian rhythm disorders. Alterations in Mtnr1b gene expression or mutations in the Mel1b receptor gene have been associated with sleep disorders, mood disorders, and even certain types of cancer. The Mel1b receptor is widely targeted in pharmacological research for the development of novel sleep aids and treatments for circadian rhythm disorders. Selective agonists or antagonists of the MT2 receptor hold promise for improving sleep quality and treating related conditions. In summary, the MT2 melatonin receptor, also known as Mel1b receptor, is a critical player in regulating the sleep-wake cycle and circadian rhythms. Understanding its function and potential therapeutic applications can have significant implications for sleep disorders and related health conditions.
Source	Rabbit
Specificity	The antibody for MTR1B is designed to identify the total amount of endogenous MTR1B present in a sample. This means that it can detect all forms of MTR1B that naturally occur within the body.
Species Reactivity	Human;Rat
Antigen	MTR1B
Application	The recommended dilution for Western Blot is between 1:500 and 1:1000, while for Immunofluorescence/Immunocytochemistry, it is between 1:100 and 1:500. For ELISA using peptide, the recommended dilution is between 1:20000 and 1:40000. Please note that this information is derived from the original text and has been rearranged to present the same content in a slightly different way.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was carried out utilizing SulfoLink™ Coupling Resin through peptide affinity chromatography. Let me provide you with a revised version of the content.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store for one year at -20 °C and avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage instructions for Rabbit IgG are as follows: Store the IgG at a temperature of -20 °C. It should be stored in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl and 0.02% sodium azide. Additionally, the IgG should be mixed with 50% glycerol before storing. The stability of the IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Tissue specificity	Expressed in retina and less in brain and hippocampus.
Celluar localization	Plasma Membrane;
UniPort	P49286