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Rabbit Anti-IGF2R Polyclonal Antibody#abs137858

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Description

Catalog-specification	Delivery time	USD price
abs137858-100ug	1-2 Weeks	301.0
abs137858-50ug	1-2 Weeks	201.0

Overview
catalog	abs137858
Other names	The 300 kDa mannose 6-phosphate receptor, also known as the cation-independent mannose-6-phosphate receptor or CD222 antigen, plays a crucial role in cellular trafficking and lysosomal enzyme targeting. It is a type I transmembrane protein with a high affinity for both mannose 6-phosphate (M6P) and insulin-like growth factor 2 (IGF2). The receptor is encoded by the IGF2R gene and is highly conserved across species. The cation-independent mannose-6-phosphate receptor is essential for proper lysosomal function and is responsible for the transport and proper targeting of lysosomal enzymes to their respective compartments. This process is crucial for the breakdown of cellular waste and proper maintenance of cellular homeostasis. In addition to its role in lysosomal function, the IGF2 receptor is also involved in the regulation of insulin-like growth factors and has been shown to act as a tumor suppressor in certain types of cancer. Dysregulation of the receptor has been implicated in the development and progression of various diseases, including cancer, lysosomal storage disorders, and neurodegenerative diseases. Overall, the mannose 6-phosphate receptor plays a crucial role in maintaining cellular health and proper lysosomal function, highlighting its importance in overall human health and disease.
Source	Rabbit
Specificity	Total IGF2R levels can be accurately detected using the IGF2R Antibody, which is designed to target the endogenous expression of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	IGF2R
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IGF2R.
MW	274kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. The resin was able to link specifically to the target peptides, resulting in a highly pure antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	For a period of one year, it is advisable to store the item at a temperature of -20 °C. It is important to avoid subjecting it to repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Celluar localization	Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Nucleus;Plasma Membrane;
UniPort	P11717