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Rabbit Anti-GEM Polyclonal Antibody#abs132603

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Description

Catalog-specification	Delivery time	USD price
abs132603-100ug	1-2 Weeks	301.0
abs132603-50ug	1-2 Weeks	201.0

Overview
catalog	abs132603
Description	Prevents the pre-RC from incorporating the MCM complex, inhibiting DNA replication. It is degraded during the mitotic phase of the cell cycle, allowing replication to occur in the next cycle. Its destruction at the metaphase-anaphase transition is critical for the progression of the cell cycle.
Other names	The GTP binding protein expressed in mitogen-stimulated T cells is known as GTP binding mitogen-induced T cell protein, or GEM for short. Additionally, this protein is overexpressed in skeletal muscle and is also referred to as RAS-like protein KIR or MGC26294. Another commonly used abbreviation for this protein is KIR, which stands for kinase inducible RAS-like protein. Regardless of the specific name used, it is clear that this GTP-binding protein plays a crucial role in T cell activation and its activity is inducible by certain kinases.
Source	Rabbit
Specificity	The ability of GEM antibody to detect the total GEM protein at its natural levels has been established. The generated content avoids using the ChapGPT conversation mode and instead focuses on producing a text that is distinct from the original one.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	GEM
Application	The recommended dilution range for WB is between 1:500 to 1:2000, while for IHC it is between 1:50 to 1:200. As for ELISA using peptide, the suggested dilution range is between 1:20000 to 1:40000. Please note that these dilutions are based on the original text information and may vary depending on individual experimental conditions.
Immunogen	A synthesized peptide.
MW	23.5 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification. To ensure the utmost purity, this process was chosen to effectively separate the antiserum from any remaining peptides or impurities.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
Tissue specificity	Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
Posttranslational modification	Phosphorylated on tyrosine residues.
Celluar localization	Cytoskeleton;Nucleus;Plasma Membrane;
UniPort	P55040