Rabbit Anti-BMP3 Polyclonal Antibody#abs131233

abs131233-50ug

1-2 Weeks

201

abs131233-100ug

1-2 Weeks

301

Description

This particular factor has an adverse effect on bone density. It acts as an antagonist, specifically targeting certain osteogenic BMPs. It obstructs the osteoprogenitor differentiation and ossification process that these BMPs can initiate.

Other names

BMP-3A is also known as osteogenin, and it falls under the category of bone morphogenetic proteins. Another variant, BMP-3, also shares similar properties. The human equivalent of BMP-3 is BMP3_HUMAN, and it plays a crucial role in promoting osteogenesis. These proteins have a significant impact on bone development and regeneration. An alternate name for BMP-3 is BMP3A, emphasizing its association with bone morphogenesis. Essentially, BMP-3 acts as a growth factor that aids in the formation of new bone tissue.

Source

Rabbit

Specificity

The total BMP3 levels can be accurately detected by the BMP3 Antibody, which specifically targets the endogenous BMP3 protein.

Application

The recommended dilution ratios for WB, IHC, IF/ICC, and ELISA (peptide) are as follows: WB should be diluted at a ratio of 1:500-1:2000, IHC at a ratio of 1:50-1:200, IF/ICC at a ratio of 1:100-1:500, and ELISA (peptide) at a ratio of 1:20000-1:40000. It is important to note these dilution guidelines when conducting experiments using these techniques.

A synthesized peptide derived from human BMP3.

Properties

1mg/ml

Purification

Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum.

Clonality

Polyclonal Antibody

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles. Take necessary precautions to ensure the product is always kept in optimal conditions.

Storage buffer

The Rabbit IgG is diluted in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM of NaCl and a small amount (0.02%) of sodium azide for preservation. Additionally, it is mixed with 50% glycerol to enhance its stability. This solution should be stored at a temperature of -20 °C. It is important to note that the Rabbit IgG remains stable for a period of 12 months starting from the date of receipt.

Target

Background

The regulation of bone density is negatively affected by this factor, which acts as an antagonist against certain osteogenic BMPs. Its role is to hinder the induction of osteoprogenitor differentiation and ossification.

Tissue specificity

Expressed in adult and fetal cartilage.

Celluar localization

P12645