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Rabbit Anti-REPS2 Polyclonal Antibody#abs139321

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Description

Catalog-specification	Delivery time	USD price
abs139321-100ug	1-2 Weeks	301.0
abs139321-50ug	1-2 Weeks	201.0

Overview
catalog	abs139321
Other names	Partner of Ral binding protein 1, also known as POB1 or RALBP1 associated Eps domain containing 2, is a key protein involved in the interaction of RalBP1. As a RALBP1 interacting protein 2, it plays a critical role in maintaining the stability of RalBP1-associated Eps domain-containing protein 2. Additionally, REPS 2 is also associated with multiple cellular processes, including endosome biogenesis, receptor recycling, and actin cytoskeleton dynamics. Overall, the complex functions of POB1 underscore its importance as a multifaceted regulatory protein in various cellular pathways.
Source	Rabbit
Specificity	The endogenous levels of total REPS2 can be accurately detected using the REPS2 Antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Pig;
Antigen	REPS2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human REPS2.
MW	72 kDa
Properties
Concentration	1mg/ml
purification	By employing SulfoLink™ Coupling Resin, the peptide affinity chromatography technique successfully purified the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage is recommended at -20 °C to maintain quality. It is important to prevent repeated freeze/thaw cycles.
Storage buffer	The storage and handling guidelines for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product is stable for 12 months from the date of receipt. Please make sure to abide by these instructions in order to maintain the optimal condition of the product.
Target
Background	Involved in growth factor signaling through its influence on the Ral signaling pathway.
Tissue specificity	Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
Posttranslational modification	EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.
Celluar localization	Cytosol;
UniPort	Q8NFH8