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Rabbit Anti-T-cadherin Polyclonal Antibody#abs131297

Description

Catalog-specification	Delivery time	USD price
abs131297-100ug	1-2 Weeks	301.0
abs131297-50ug	1-2 Weeks	201.0

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Overview
catalog	abs131297
Description	Calcium-dependent cell adhesion proteins are known as cadherins. These proteins play a crucial role in connecting cells in a homophilic manner, thus contributing to the sorting of various cell types. Moreover, cadherins are believed to act as negative regulators of neural cell growth. Due to their unique ability to bind to other cadherin molecules, these proteins are responsible for maintaining the structural integrity of cells and tissues. Cadherins have emerged as key players in several cellular processes, including development, cell signaling, and disease progression.
Other names	CDH13, also known as Cadherin-13 or H-cadherin, is a protein encoded by the CDH13 gene. It is also referred to as CDHH or P105. T cad, T Cadherin, and T-cad are other names associated with this protein. CDH13 is primarily expressed in the heart and plays a crucial role in cell adhesion and tissue development. Cadherins are a family of transmembrane proteins that mediate calcium-dependent cell-cell adhesion. CDH13 belongs to the cadherin superfamily and serves as an important regulator of cell communication and interactions. It is involved in various biological processes, including embryogenesis, morphogenesis, and tissue formation. The specific function of CDH13 in the heart is not fully understood, but it is thought to contribute to the maintenance of tissue integrity and cell arrangement within the organ. It interacts with other cadherins and forms adherens junctions, which are crucial for the stability and mechanical strength of tissues. Interestingly, CDH13 has been associated with several diseases and conditions. Genetic variations in the CDH13 gene have been linked to an increased susceptibility to cardiovascular diseases, such as hypertension, myocardial infarction, and atherosclerosis. Additionally, altered CDH13 expression has been observed in various cancers, including breast, colorectal, and lung cancers. In conclusion, CDH13 is an important protein involved in cell adhesion and tissue development, particularly in the heart. Its dysregulation has been implicated in cardiovascular diseases and cancer. Further research on CDH13 can provide insights into the molecular mechanisms underlying these conditions and potentially lead to the development of novel therapeutic strategies.
Source	Rabbit
Specificity	The total T-cadherin antibody is capable of detecting the naturally occurring levels of T-cadherin within the body. This antibody specifically targets and binds to T-cadherin, allowing for the accurate measurement of its presence. By utilizing this antibody, researchers can gain valuable insights into the endogenous levels of T-cadherin and its potential role in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	T-cadherin
Application	The dilutions for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC-p) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000.
Immunogen	A newly produced peptide has been created from human T-cadherin using synthesized methods. The nature of this peptide has been carefully derived to closely resemble the original T-cadherin structure. This newly synthesized peptide is expected to have a similar effect as the original T-cadherin and may prove useful for further studies and applications in the field of biomedicine. The scientific breakthrough in creating this peptide from human T-cadherin indicates progress in our understanding of the human body and its functions.
MW	78 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. For purification, this process was found to be highly effective, resulting in a high-quality product.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Tissue specificity	Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P55290