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Rabbit Anti-IgA Polyclonal Antibody#abs138083

Description

Catalog-specification	Delivery time	USD price
abs138083-100ug	1-2 Weeks	301.0
abs138083-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138083
Other names	： Ig alpha 1 chain C region, also known as IgA1 or IGHA1, is a protein encoded by the FLJ14473 gene. It is part of the immunoglobulin heavy constant alpha 1 chain. FLJ35065, FLJ35500, FLJ36402, FLJ39698, FLJ40001, FLJ41548, FLJ41552, FLJ41789, FLJ43248, FLJ43594, FLJ44293, FLJ46028, FLJ46621, FLJ46724, FLJ46811, FLJ46824, and FLJ90170 are other genes that encode proteins related to Ig alpha 1 chain C region. Another protein, Ig alpha 2 chain C region, is encoded by the IGHA2 gene. It is also known as IgA2 or A2m marker. The protein is part of the immunoglobulin heavy constant alpha 2 chain. MGC102857 is another name associated with IGHA2 protein. The protein is also referred to as Immunoglobulin A2 or Immunoglobulin Am2. It is related to the immunoglobulin heavy constant alpha 2 (A2m marker). Thus, these genes and proteins are important components of the immune system and play a role in antibody production. The rearrangement of the content provides a concise overview of the genes and proteins involved, giving an understanding of their names and functions.
Source	Rabbit
Specificity	The total level of IgA in the body can be measured using the IgA antibody.
Species Reactivity	Human;Rat
Antigen	IgA
Application	The recommended dilution for Western blotting is 1:1000 to 1:3000, for immunohistochemistry it is 1:200, and for ELISA with peptides it is 1:20000 to 1:40000. Please note that the dilutions mentioned above are based on the original information provided and should be followed accordingly.
Immunogen	A synthesized peptide derived from human IgA.
MW	37 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was isolated through peptide affinity chromatography. A highly purified form was achieved in the process.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the material, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to prevent repeated freezing and thawing cycles in order to maintain the integrity of the substance.
Storage buffer	This product is Rabbit IgG that is stored in phosphate buffered saline with a pH of 7.4 and contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain the quality of the product, it should be kept at a temperature of -20 °C and can be stored for up to 12 months from the date of receipt.
Target
Background	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Posttranslational modification	3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P01876/P01877