Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-IDH3B Polyclonal Antibody#abs138082

Please note that the price mentioned above is for your reference only. For detailed pricing information, we suggest you contact our seller, Vecent. It's important to understand that the information provided is based on the original text and we recommend generating similar content by rearranging...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs138082-100ug	1-2 Weeks	301.0
abs138082-50ug	1-2 Weeks	201.0

Overview
catalog	abs138082
Other names	The FLJ11043, also known as H-IDHB or Idh3B, encodes the isocitrate dehydrogenase [NAD] subunit beta, which is primarily located in the mitochondria. This enzyme is involved in the citric acid cycle and plays a crucial role in energy production. It catalyzes the conversion of isocitrate to alpha-ketoglutarate, producing NADH in the process. The IDH3B_HUMAN gene is also referred to as isocitric dehydrogenase subunit beta or NAD+-specific isocitrate dehydrogenase beta. Its function is to oxidatively decarboxylate isocitrate and produce NADH, which is a key cofactor in cell metabolism. In addition to its energy-producing functions, IDH3B also plays a role in various cellular processes, including redox regulation, gene expression, and differentiation. Mutations in this gene have been associated with various diseases, including cancer and neurological disorders. Overall, the IDH3B gene is a crucial player in metabolism and cellular function, and its study is critical in understanding these processes in normal and disease states.
Source	Rabbit
Specificity	The IDH3B antibody is specifically designed to identify the total IDH3B levels present in the body. It effectively recognizes endogenous levels of the protein and provides accurate results. To generate highly similar content based on this information, one could say that the IDH3B antibody is capable of detecting the overall amount of IDH3B present within the individual. Its efficacy in identifying endogenous levels of the protein is noteworthy, making it a valuable tool for research and diagnostic purposes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse;Pig;
Antigen	IDH3B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IDH3B.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product for a duration of one year at a temperature of -20 °C. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Celluar localization	Mitochondrion;Nucleus;
UniPort	O43837