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Rabbit Anti-TRPM7 Polyclonal Antibody#abs137777

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Description

Catalog-specification	Delivery time	USD price
abs137777-100ug	1-2 Weeks	301.0
abs137777-50ug	1-2 Weeks	201.0

Overview
catalog	abs137777
Other names	Possible highly similar content: TRPM7, also known as transient receptor potential cation channel subfamily M member 7, is a channel kinase that plays a crucial role in various physiological processes. It is encoded by the ALSPDC or CHAK1 gene and may be referred to as Channel kinase 1 or Channel-kinase 1. Another name for TRPM7 is Long transient receptor potential channel 7 or LTrpC-7, as it belongs to the family of long TRP channels. In some literature, it is also called TRP PLIK, which stands for TRP polycystic kidney disease-like ion channel. TRPM7 is a multifunctional protein that acts as both an ion channel and a kinase. The channel function allows TRPM7 to transport diverse ions, such as calcium, magnesium, zinc, and manganese, across cell membranes, which can affect cellular signaling, metabolism, and survival. The kinase activity of TRPM7 enables it to phosphorylate various substrates, including itself, and regulate downstream signaling pathways. Moreover, TRPM7 has been implicated in ion homeostasis, cytoskeletal dynamics, cell proliferation, differentiation, migration, and death. Mutations or dysregulation of TRPM7 have been associated with several human diseases, such as neurodegeneration, cardiac arrhythmia, renal dysfunction, and cancer. Therefore, TRPM7 has become an attractive target for drug development and therapeutic intervention. However, much remains to be learned about the precise mechanisms and functions of TRPM7 in health and disease. Ongoing research is uncovering new insights into the structure, regulation, and interaction partners of TRPM7 and its potential as a diagnostic, prognostic, and therapeutic biomarker.
Source	Rabbit
Specificity	The TRPM7 Antibody is capable of detecting total TRPM7 at levels that occur naturally within the body. This means that it is specifically designed to target and bind to the endogenous form of the protein. Through its unique properties, this antibody can provide insight into the levels and distribution of TRPM7 in various tissues and cells. By generating highly similar content based on the original text information, we can better understand the critical role that TRPM7 plays in regulating a variety of physiological processes.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;
Antigen	TRPM7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TRPM7.
MW	213 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used in the peptide affinity chromatography purification process of the antiserum. The resulting product was highly pure and free from unwanted contaminants.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store the item for a duration of one year at a temperature of -20 °C. It is important to prevent the item from going through multiple cycles of freezing and thawing.
Storage buffer	This product consists of Rabbit IgG dissolved in phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20 °C. It has a stability period of 12 months from the date of receipt.
Target
Background	Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Posttranslational modification	Autophosphorylated.
Celluar localization	Plasma Membrane;
UniPort	Q96QT4