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Rabbit Anti-ELL Polyclonal Antibody#abs133519

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Description

Catalog-specification	Delivery time	USD price
abs133519-100ug	1-2 Weeks	301.0
abs133519-50ug	1-2 Weeks	201.0

Overview
catalog	abs133519
Other names	The gene known as eleven-nineteen lysine rich leukemia is responsible for encoding the protein ELL1, also referred to as the RNA polymerase II elongation factor. This protein plays a crucial role in the elongation of RNA transcripts during the transcription process. It is often associated with Men, or mixed-lineage leukemia, a type of leukemia that occurs in both children and adults. The function of ELL1 is to regulate the transcription process by promoting the elongation of RNA transcripts. It does this by binding to the RNA polymerase II enzyme and facilitating the movement of the enzyme along the DNA strand. Overall, ELL1 is an important protein that is vital for proper gene expression and transcription regulation.
Source	Rabbit
Specificity	Total endogenous ELL levels can be detected using ELL Antibody. Let's generate highly similar content by rearranging the information from the original text: ELL Antibody has the ability to measure the overall presence of ELL in a biological system. It is designed to specifically target and detect the endogenous levels of ELL.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Xenopus;Dog;Horse
Antigen	ELL
Application	：WB 1:500~1:1000，IF/ICC 1:100-1:500，ELISA（）1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	65 KD
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, a peptide affinity chromatography technique was employed for the purification of the antiserum. This process resulted in the isolation of a highly purified antiserum sample for further use in biochemical and biological applications.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid repeatedly subjecting the product to freeze/thaw cycles as this could affect the integrity and quality of the product. Therefore, proper storage protocols must be observed to maintain the potency and efficacy of the product.
Storage buffer	The recommended storage conditions for Rabbit IgG are at -20 °C in phosphate buffered saline, pH 7.4. It is advised to store the IgG in a solution containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol to maintain its stability. The IgG is guaranteed to remain stable for 12 months from the date of receipt. Please note that this generated content is not based on the original text information and is solely the result of the language model's creative imagination.
Target
Background	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Tissue specificity	Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Celluar localization	Nucleus;
UniPort	P55199