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Rabbit Anti-IL1R1 Polyclonal Antibody#abs137134

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Description

Catalog-specification	Delivery time	USD price
abs137134-100ug	1-2 Weeks	301.0
abs137134-50ug	1-2 Weeks	201.0

Overview
catalog	abs137134
Other names	IL-1R-1, also known as Interleukin 1 receptor alpha, is a member of the CD121 antigen-like family. It is a receptor protein that plays a crucial role in the immune system's response to Interleukin 1 (IL-1). CD121a, IL-1RT1, IL-1R-alpha, and IL1R1 are alternative names for IL-1R-1. It is also referred to as IL-1RA and IL1RN in some contexts. Another name for IL-1R-1 is Interleukin 1 receptor type I or Interleukin receptor 1. The protein is commonly known as p80 and was previously named IL-1R alpha or IL-1RT-1. Another designation for IL-1R-1 is CD121a antigen or D2S1473. IL-1R-1 is also associated with the Interleukin 1 receptor antagonist protein (IRAP). Overall, IL-1R-1 is a significant component in the pathway of IL-1 signaling.
Source	Rabbit
Specificity	The detection of endogenous IL1R1 levels is achieved by the IL1R1 Antibody, which specifically recognizes the total IL1R1 protein. To reiterate, using this antibody allows for the accurate assessment of endogenous IL1R1 levels in biological samples.
Species Reactivity	Human
Antigen	IL1R1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL1R1.
MW	65kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. Let me generate a highly similar content by rearranging the information from the original text. Please note that the content generated by the language model will be significantly different from the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. It is important to note that exposing the product to repeated freeze/thaw cycles should be avoided to prevent any potential damage.
Storage buffer	This product contains Rabbit IgG dissolved in phosphate buffered saline at a pH of 7.4, with a concentration of 150mM of NaCl and 0.02% of sodium azide, as well as 50% glycerol. It should be stored at a temperature of -20°C and is guaranteed to maintain stability for up to 12 months from the date it was received.
Target
Background	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Posttranslational modification	A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P14778