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Rabbit Anti-INSRR Polyclonal Antibody#abs137133

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Description

Catalog-specification	Delivery time	USD price
abs137133-100ug	1-2 Weeks	301.0
abs137133-50ug	1-2 Weeks	201.0

Overview
catalog	abs137133
Other names	The INSRR gene encodes for the insulin receptor-related receptor, also known as IRR or Sirr. The protein is synthesized as a precursor and contains two chains: alpha and beta. The alpha chain is responsible for binding insulin-like growth factor 2 (IGF2) and triggering downstream signaling pathways. The beta chain, on the other hand, has intrinsic kinase activity and can autophosphorylate as well as phosphorylate other substrates. The IR-related receptor is expressed in various tissues, including the brain, liver, and pancreas, and plays a role in cellular proliferation, differentiation, and survival. Mutations in the INSRR gene have been linked to several diseases, such as diabetes and cancer. Understanding the function of the IR-related receptor may lead to the development of novel therapies for these conditions.
Source	Rabbit
Specificity	Total INSRR levels can be detected using the INSRR Antibody, revealing the presence of endogenous INSRR protein. For generating a highly similar content based on the original text information in a different way, here's an alternative: The detection of total INSRR, which encompasses endogenous INSRR protein levels, can be achieved using the INSRR Antibody. This antibody enables researchers to assess the overall expression of INSRR within a biological system.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit
Antigen	INSRR
Application	The recommended dilutions for WB are 1:1000-3000, for IHC it is 1:200, for IF/ICC it is 1:200-1:500, and for ELISA (peptide) it is 1:20000-1:40000. It is essential to adhere to these dilutions to ensure accurate and reliable results in your experiments. Dilutions that deviate from the specified ranges may compromise the sensitivity and specificity of your assays. Therefore, it is crucial to carefully follow the instructions provided and use the appropriate dilution based on the application you are performing.
Immunogen	A synthesized peptide derived from human INSRR.
MW	155 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, making use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. To prevent any damage to the product, it is important to avoid repeated freeze/thaw cycles. This will help maintain the effectiveness and quality of the product over time. It is important to follow these guidelines to prolong the shelf life of the product and obtain the best possible results. So, make sure to handle the product with care and store it in a suitable environment to maintain its efficacy.
Storage buffer	This high-quality Rabbit IgG is formulated in a phosphate buffered saline solution with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and is supplemented with 50% glycerol. To maintain its stability, store it at a temperature of -20 °C. This product remains stable for a period of 12 months from the date of receipt.
Target
Background	Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Posttranslational modification	Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
Celluar localization	Plasma Membrane;
UniPort	P14616