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Rabbit Anti-SIAH2 Polyclonal Antibody#abs131554

Rabbit Anti-SIAH2 Polyclonal Antibody#abs131554

Please note that the mentioned price is for your reference only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specificationDelivery timeUSD price

abs131554-50ug

1-2 Weeks

201.0

abs131554-100ug

1-2 Weeks

301.0

Please note that the mentioned price is for your reference only. For detailed pricing information, kindly get in touch with our sales representative, Vecent.


Overview

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abs131554

Description

An E3 ubiquitin-protein ligase is a critical player that facilitates the removal of specific target proteins through ubiquitination and subsequent proteasomal degradation. These ligases receive ubiquitin from an E2 ubiquitin-conjugating enzyme and then directly transfer it to the intended substrates, marking them for degradation. The thioester linkage between the E2 enzyme and ubiquitin enables the E3 ligase to perform this transfer with precision and accuracy. The role of E3 ubiquitin ligases is essential for maintaining proper cellular homeostasis by appropriately regulating protein levels and turnover.

Other namesThe E3 ubiquitin-protein ligase Siah2, also known as hSiah2 or Seven in absentia homolog 2, is a vital protein in the human body. This protein, encoded by the SIAH2 gene, is responsible for the transfer of ubiquitin, an essential protein, to target proteins for degradation. It also plays a critical role in cellular signaling pathways, including apoptosis, hypoxia, and inflammation. Siah E3 ubiquitin protein ligase 2 is one of the two genes in the Siah family, the other being Siah1. However, Siah2 is the more highly studied of the two. It is involved in several biological processes, including protein modification, cell differentiation, and cellular response to stress. Ubiquitin ligase Siah2 is a potent regulator of protein turnover, and its activity is crucial for maintaining cellular homeostasis. Overall, Siah2 is an essential protein in the human body, and its dysregulation has been linked to several diseases, including cancer, neurodegeneration, and cardiovascular diseases.
SourceRabbit
SpecificityThe SIAH2 Antibody is capable of detecting the total amount of endogenous SIAH2 protein. To provide a similar content but with a different arrangement, please note that the SIAH2 Antibody can effectively recognize and measure the levels of SIAH2 protein present in a biological sample. This antibody allows researchers to accurately assess the overall quantity of SIAH2 in a specific biological context.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Xenopus;Sheep;Bovine;Rabbit;Chicken;
AntigenSIAH2
ApplicationThe dilution ratios for various applications are as follows: WB (1:500-1:2000), IHC (1:50-1:200), IF (1:100-1:500), and ELISA (peptide) (1:20000-1:40000). These dilutions are crucial for achieving accurate results in experimental procedures. It is advisable to carefully follow the recommended dilution range specific to each application to ensure optimal outcomes. The wide range of dilutions allows flexibility in selecting the appropriate concentration for different experimental conditions.
ImmunogenA synthesized peptide derived from human SIAH2.
MW36 kDa
Properties

Concentration

1mg/ml

purificationThrough the use of SulfoLink™ Coupling Resin, purification of the antiserum was achieved via peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Tissue specificityUbiquitous.
Celluar localizationCytosol;Endoplasmic reticulum;Nucleus;
UniPortO00255


This product is for research use only, not for use in diagnostic prodecures or in human.


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