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Rabbit Anti-LFNG Polyclonal Antibody#abs140915

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Description

Catalog-specification	Delivery time	USD price
abs140915-100ug	1-2 Weeks	301.0
abs140915-50ug	1-2 Weeks	201.0

Overview
catalog	abs140915
Other names	Lunatic fringe, also known as 3-N-acetylglucosaminyltransferase, is an enzyme involved in O-fucosylation. It plays a crucial role in the modification of proteins by adding N-acetylglucosamine to specific sites. The gene responsible for encoding this enzyme is known as lfng or LFNG_HUMAN. In addition to its involvement in protein glycosylation, lunatic fringe is also linked to developmental processes, particularly in embryogenesis. Another related enzyme, beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, is also involved in O-fucosylation. It shares similarities with lunatic fringe but has its own distinct functions and characteristics. The gene associated with beta-1,3-N-acetylglucosaminyltransferase lunatic fringe is SCDO3. Understanding and studying these enzymes can provide valuable insights into the complex mechanisms of protein modifications and their impact on various biological processes. Further research and exploration of lunatic fringe and beta-1,3-N-acetylglucosaminyltransferase lunatic fringe hold promises for advancements in the field of glycobiology and related areas of biomedical research.
Source	Rabbit
Specificity	The LFNG Antibody is capable of recognizing the total LFNG levels present within an organism. This ability allows for the detection of the endogenous quantity of LFNG produced, which is useful for a variety of research purposes. By generating a new variation of this information, it is possible to convey the same meaning in a different way.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	LFNG
Application	For western blotting, a recommended dilution range is 1:500 to 1:1000. When performing immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is suggested. For ELISA using a peptide substrate, a dilution range of 1:20000 to 1:40000 is appropriate. It is important to follow dilution guidelines to ensure accurate and reliable experimental results.
Immunogen	A synthesized peptide.
MW	42 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, and SulfoLink™ Coupling Resin was utilized for the process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, it is recommended to keep the material at a temperature of -20°C for a period of one year. It is important to avoid repeatedly freezing and thawing the substance to prevent damage or alteration of its properties. Take measures to prevent any damage to the material during storage to maintain its integrity and quality.
Storage buffer	This rabbit IgG comes in phosphate buffered saline, pH 7.4, with 150mM NaCl and 0.02% sodium azide. It also contains 50% glycerol and should be stored at -20 °C. You can expect it to remain stable for 12 months from the date of receipt, making it a reliable choice for your scientific research needs.
Target
Background	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity).
Posttranslational modification	A soluble form may be derived from the membrane form by proteolytic processing.
Celluar localization	Extracellular region or secreted;Golgi apparatus;
UniPort	Q8NES3