Rabbit Anti-FRS2 Polyclonal Antibody #abs130046

abs130046-50ug

1-2 Weeks

201

abs130046-100ug

1-2 Weeks

301

Description

FRS2 is a crucial adaptor protein essential for the proper functioning of the fibroblast growth factor receptor (FGFR) signaling pathway. Its primary role involves connecting FGFR and nerve growth factor receptors to the Ras/MAPK signaling pathways, thereby facilitating effective communication between these pathways. This information is based on UniProtKB and is intended to generate highly similar content.

Other names

Sure! Here's a rearranged version of the given content:
Fibroblast growth factor receptor substrate 2, also known as FGFR signalling adaptor SNT or FGFR-signaling adaptor, is a protein involved in FGFR signaling pathways. It is encoded by the FRS2 gene and is alternatively known as FRS2A or FRS2alpha. SNT 1, alias of Suc 1 Associated Neurotrophic Factor Target 1, is another name associated with this protein.
FRS2 acts as an adaptor or substrate for FGFRs and plays a crucial role in transmitting signals from FGFRs to downstream effectors. It is involved in various cellular processes like cell growth, proliferation, differentiation, and migration.
The protein SNT, or Suc1-associated neurotrophic factor target 1, is associated with FRS2 and further contributes to its function in FGFR signaling. SNT1 acts as a mediator in the intracellular pathways regulated by FGFRs and is believed to enhance the efficiency of signal transduction.
Overall, FRS2 and SNT1 are key components of FGFR signaling, facilitating the transmission of signals and modulating cellular responses in various physiological and pathological contexts.

Source

Rabbit

Specificity

The antibody FRS2 is capable of detecting the complete endogenous levels of FRS2. This implies that the FRS2 antibody can identify all forms and variations of FRS2 present within a sample and provide a comprehensive analysis of FRS2 in a biological system.

Species Reactivity

Human;Mouse

Application

WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human FRS2.

Properties

Concentration

1mg/ml

Purification

Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality, keep the store temperature at -20 °C for one year. Make sure to prevent the occurrence of freeze/thaw cycles that could potentially damage the product.

Storage buffer

The recommended storage conditions for Rabbit IgG are as follows: keep it at a temperature of -20 °C. The IgG should be stored in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the IgG is stable for a period of 12 months from the date of receipt. Following these storage guidelines will help maintain the quality and integrity of the Rabbit IgG.

Target

Background

This protein functions as an adaptor between NGF receptors and activated FGR, aiding in the activation of downstream signaling pathways. Its role in activating MAP kinases and phosphorylating PIK3R1 in response to FGFR1 ligand activation is crucial. By competing for a shared binding site on NTRK1, it also regulates signaling via SHC1. These functions underscore the protein's importance in modulating key signaling pathways.

Tissue specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Posttranslational modification

Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).

Celluar localization

Endosome;Plasma Membrane;

UniPort

Q8WU20