Rabbit Anti-LEF-1 Polyclonal Antibody #abs123780

abs123780-50ul

In Stock

201

abs123780-100ul

In Stock

301

Other names

Lymphoid Enhancing Factor-1, also known as Transcription Factor T Cell Specific 1 Alpha or LEF1, is a protein that plays a crucial role in the development and differentiation of T cells. It is encoded by the DKFZp586H0919 gene and is highly expressed in the thymus, where it regulates the expression of genes involved in T cell development.
LEF1 belongs to the TCF/LEF family of transcription factors, which are involved in the Wnt signaling pathway. It binds to specific DNA sequences and activates transcription of target genes, including those involved in lymphoid cell differentiation. LEF1 also interacts with beta-catenin, a key downstream effector of Wnt signaling, to regulate cell proliferation and differentiation.
Defects in LEF1 have been associated with a variety of diseases, including cancer, rheumatoid arthritis, and celiac disease. As a result, LEF1 has become an important target for therapeutic intervention in these conditions.
In conclusion, LEF1 is a critical regulator of T cell development and differentiation, and its dysregulation can lead to various pathological conditions. Further research on the mechanisms of LEF1 action may lead to new therapeutic strategies for these diseases.

Source

Rabbit

Specificity

LEF-1

Species Reactivity

Human;Mouse;Rat;Chicken;Dog;Pig;Cow;Rabbit;

Application

WB=1:500-2000 ELISA=1:500-1000

Immunogen

Synthetic peptide KLH conjugated, derived from human LEF-1:331-399/399, is available. We can create equivalent content by rearranging the given information, ensuring that the generated text is based on the original information. However, instead of following the conversation-style content generation approach of ChapGPT, we will utilize a language model to produce text in a completely different manner.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To ensure the preservation of the item, it is advised to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting it to repeated cycles of freezing and thawing.

Storage buffer

，：pH7.40.01M TBS，1% BSA、0.03% Proclin30050%。。

Research area

Immunology

Target

Background

The protein encoded by this gene is a transcription factor that belongs to a family of proteins similar to high mobility group protein-1. It plays a crucial role in the T-cell receptor-alpha enhancer by binding to an important site, which enhances its activity significantly. Additionally, this transcription factor is involved in the Wnt signaling pathway and may contribute to the differentiation of hair cells and the formation of hair follicles. Interestingly, mutations in this gene have been identified in somatic sebaceous tumors. Moreover, this gene is associated with various cancers, including androgen-independent prostate cancer. It is worth noting that alternative splicing produces multiple transcript variants of this gene. These findings are based on information provided by RefSeq in October 2009.

Celluar localization

Nucleus

UniPort

Q9UJU2