Rabbit Anti-Podocin Polyclonal Antibody#abs138113
Please note that the price mentioned above is for reference only. To obtain more detailed information regarding the price, please do not hesitate to get in touch with our knowledgeable seller, Vecent. Western blot analysis Podocin using HuvEc whole cell lysates This product is for research use...
Description
| Catalog-specification | Delivery time | USD price |
abs138113-100ug | 1-2 Weeks | 301.0 |
abs138113-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is for reference only. To obtain more detailed information regarding the price, please do not hesitate to get in touch with our knowledgeable seller, Vecent.
| Overview | |
catalog | abs138113 |
| Other names | Idiopathic steroid-resistant nephrosis, also known as nephrosis 2, can be caused by mutations in the NPHS2 gene which codes for podocin. Podocin plays an important role in maintaining the integrity of the filtration barrier in the kidney. When podocin is defective or absent, it can lead to proteinuria and nephrosis. This condition is difficult to treat as it does not respond to steroid therapy. Patients with SRN1 have a poor prognosis and often require renal replacement therapy. It is important to identify early signs of nephrosis 2 and manage the condition appropriately to prevent further kidney damage. |
| Source | Rabbit |
| Specificity | The total Podocin levels in the body can be effectively detected using the Podocin Antibody, which specifically targets the endogenous form of Podocin. For accurate measurements, this antibody is employed to assess the overall amount of Podocin present in biological samples. |
| Species Reactivity | Human |
| Predictive reaction species | Sheep;Bovine;Horse |
| Antigen | Podocin |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide derived from human Podocin. |
| MW | 42 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure high quality and purity, this process was carefully executed. By specifically targeting peptides through the resin, the resulting antiserum was optimized for its intended use. Overall, this procedure was an effective way to isolate and purify the necessary proteins for the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure the longevity of this product, store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can negatively impact its efficacy. Please take these storage instructions into consideration to maintain the quality of the product. |
| Storage buffer | Storage instructions for Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol are as follows: Store at a temperature of -20°C. This product has a stable shelf-life of 12 months from the time of its receipt. To ensure the product remains usable for its entire shelf-life, it is important to carefully observe the recommended storage temperature and conditions. Please note that this information is provided solely for the purpose of ensuring the product's optimal performance. |
Target | |
Background | Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
| Tissue specificity | Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli. |
| Posttranslational modification | Isoform 2 is glycosylated. |
| Celluar localization | Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane; |
| UniPort | Q9NP85 |
Western blot analysis Podocin using HuvEc whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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