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Rabbit Anti-SDC1 Polyclonal Antibody#abs135109

Description

Catalog-specification	Delivery time	USD price
abs135109-50ug	1-2 Weeks	201.0
abs135109-100ug	1-2 Weeks	301.0

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Overview
catalog	abs135109
Other names	CD antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; syndecan proteoglycan 1; Syndecan-1. CD138 antigen, also known as Syndecan-1, is a cell surface protein widely expressed in various tissues and cells. It plays a crucial role in cell-cell communication and cellular processes. Syndecan-1 is a member of the syndecan proteoglycan family, which includes other members such as Syndecan-2 and Syndecan-3. The protein consists of a core protein attached to heparan sulfate chains, which contribute to its functional properties. CD138 is a key regulator of the fibroblast growth factor receptor (FGFR) signaling pathway. It is involved in the binding and presentation of fibroblast growth factors (FGFs) to FGFRs, thereby promoting cellular proliferation, migration, and differentiation. The interaction between CD138 and FGFRs is mediated by heparan sulfate chains, which act as co-receptors for FGFs. CD138 is primarily found on the cell surface of plasma cells, a type of immune cell responsible for producing antibodies. It is commonly used as a marker for plasma cells in laboratory experiments and diagnostic tests. CD138 plays a crucial role in the development and function of plasma cells, as well as the regulation of immune responses. The expression and function of CD138 are not limited to plasma cells. It is also found on other cell types, including fibroblasts, epithelial cells, and endothelial cells, where it participates in various cellular processes such as cell adhesion, migration, and tumor progression. In summary, CD138, or Syndecan-1, is a multifunctional cell surface protein involved in cell-cell communication, FGFR signaling, and immune responses. Its presence on various cell types underscores its importance in maintaining tissue homeostasis and regulating cellular processes.
Source	Rabbit
Specificity	The SDC1 Antibody is capable of identifying total SDC1 levels that occur naturally in the body. The antibody can recognize and bind to the endogenous expression of SDC1. If present, this antibody will detect the total SDC1 levels in the sample.
Species Reactivity	Human;Rat
Antigen	SDC1
Application	For Western Blotting, the recommended dilution range is between 1:500 to 1:1000. When it comes to IF/ICC assays, the recommended dilution range is between 1:100 to 1:500. Finally, for ELISA using peptide as an antigen, the recommended dilution range is between 1:20000 to 1:40000. It is important to keep in mind these recommended dilution ranges when designing and conducting experiments in order to obtain optimal results.
Immunogen	A synthesized peptide.
MW	32 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain quality, it is recommended to keep the product at a temperature of -20 °C for up to 12 months. To prevent any damage or alteration to the product, avoid subjecting it to multiple freeze-thaw cycles.
Storage buffer	The Rabbit IgG solution comes in a formula consisting of phosphate buffered saline with pH 7.4, 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is highly recommended to store the solution at -20 °C. The solution can remain stable for up to 12 months from the date of receipt.
Target
Background	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Posttranslational modification	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Lysosome;Plasma Membrane;
UniPort	P18827